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Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes

Summary Background & aims Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes. Although dietary fat contributes substantially to the accumulation of liver fat, the role of individual fatty acids in this accumulation is unclear. Ob...

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Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2012-08, Vol.31 (4), p.520-525
Main Authors: Petit, J.M, Guiu, B, Duvillard, L, Jooste, V, Brindisi, M.C, Athias, A, Bouillet, B, Habchi, M, Cottet, V, Gambert, P, Hillon, P, Cercueil, J.P, Verges, B
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creator Petit, J.M
Guiu, B
Duvillard, L
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Hillon, P
Cercueil, J.P
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description Summary Background & aims Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes. Although dietary fat contributes substantially to the accumulation of liver fat, the role of individual fatty acids in this accumulation is unclear. Objective In this study, we set out to determine whether liver fat content (LFC), was associated with red blood cell fatty acid (RBC-FA) composition in people with type 2 diabetes. Design, settings, and participants One hundred and sixty-two type 2 diabetic patients were included in this study. LFC was measured using1 H-MR Spectroscopy. RBC-FA composition was measured by gas chromatography. Results One hundred and nine (67.2%) patients had steatosis. Patients with steatosis had a higher BMI ( p = 0.0005), and higher plasma triglyceride levels ( p = 0.009) than did patients without steatosis. We report a significant association between palmitic acid (16:0), palmitoleic acid (16:1n-7) concentrations and ratio of monounsaturated to saturated fatty acid (palmitoleic acid to palmitic acid) and higher liver fat content. Total polyunsaturated fatty acid (PUFA), homo-gamma-linolenic acid (20:3n-6), docosahexaenoic acid (22:6n-3), and arachidonic acid (20:4 n-6) were associated with lower LFC. Conclusions Our data showed that an increased erythrocytes long-chain n-3 and n-6 fatty acids was associated with a lower prevalence of steatosis in patients with type 2 diabetes. These results suggest that n-3 and n-6 fatty acids supplementation could be a promising treatment for NAFLD in patients with type 2 diabetes.
doi_str_mv 10.1016/j.clnu.2011.12.007
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Although dietary fat contributes substantially to the accumulation of liver fat, the role of individual fatty acids in this accumulation is unclear. Objective In this study, we set out to determine whether liver fat content (LFC), was associated with red blood cell fatty acid (RBC-FA) composition in people with type 2 diabetes. Design, settings, and participants One hundred and sixty-two type 2 diabetic patients were included in this study. LFC was measured using1 H-MR Spectroscopy. RBC-FA composition was measured by gas chromatography. Results One hundred and nine (67.2%) patients had steatosis. Patients with steatosis had a higher BMI ( p = 0.0005), and higher plasma triglyceride levels ( p = 0.009) than did patients without steatosis. We report a significant association between palmitic acid (16:0), palmitoleic acid (16:1n-7) concentrations and ratio of monounsaturated to saturated fatty acid (palmitoleic acid to palmitic acid) and higher liver fat content. Total polyunsaturated fatty acid (PUFA), homo-gamma-linolenic acid (20:3n-6), docosahexaenoic acid (22:6n-3), and arachidonic acid (20:4 n-6) were associated with lower LFC. Conclusions Our data showed that an increased erythrocytes long-chain n-3 and n-6 fatty acids was associated with a lower prevalence of steatosis in patients with type 2 diabetes. These results suggest that n-3 and n-6 fatty acids supplementation could be a promising treatment for NAFLD in patients with type 2 diabetes.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2011.12.007</identifier><identifier>PMID: 22209679</identifier><identifier>CODEN: CLNUDP</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged ; Biological and medical sciences ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Dietary Fats - administration &amp; dosage ; Dietary Supplements ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Erythrocytes - chemistry ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty acid composition ; Fatty Acids, Monounsaturated - analysis ; Fatty Acids, Monounsaturated - metabolism ; Fatty Acids, Omega-3 - administration &amp; dosage ; Fatty Acids, Omega-3 - blood ; Fatty Acids, Omega-6 - administration &amp; dosage ; Fatty Acids, Omega-6 - blood ; Fatty Liver - complications ; Fatty Liver - physiopathology ; Fatty Liver - prevention &amp; control ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Humans ; Male ; Medical sciences ; Middle Aged ; Non-alcoholic Fatty Liver Disease ; Palmitic Acid - analysis ; Palmitic Acid - metabolism ; Prevalence ; Prospective Studies ; PUFA ; Steatosis ; Triglycerides - blood ; Type 2 diabetes ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2012-08, Vol.31 (4), p.520-525</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-50482a0261103b2432092cbb963a80eab3a22049c930276e825988a0800e3ebb3</citedby><cites>FETCH-LOGICAL-c441t-50482a0261103b2432092cbb963a80eab3a22049c930276e825988a0800e3ebb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=26192501$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22209679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petit, J.M</creatorcontrib><creatorcontrib>Guiu, B</creatorcontrib><creatorcontrib>Duvillard, L</creatorcontrib><creatorcontrib>Jooste, V</creatorcontrib><creatorcontrib>Brindisi, M.C</creatorcontrib><creatorcontrib>Athias, A</creatorcontrib><creatorcontrib>Bouillet, B</creatorcontrib><creatorcontrib>Habchi, M</creatorcontrib><creatorcontrib>Cottet, V</creatorcontrib><creatorcontrib>Gambert, P</creatorcontrib><creatorcontrib>Hillon, P</creatorcontrib><creatorcontrib>Cercueil, J.P</creatorcontrib><creatorcontrib>Verges, B</creatorcontrib><title>Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Summary Background &amp; aims Non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, metabolic syndrome and type 2 diabetes. Although dietary fat contributes substantially to the accumulation of liver fat, the role of individual fatty acids in this accumulation is unclear. Objective In this study, we set out to determine whether liver fat content (LFC), was associated with red blood cell fatty acid (RBC-FA) composition in people with type 2 diabetes. Design, settings, and participants One hundred and sixty-two type 2 diabetic patients were included in this study. LFC was measured using1 H-MR Spectroscopy. RBC-FA composition was measured by gas chromatography. Results One hundred and nine (67.2%) patients had steatosis. Patients with steatosis had a higher BMI ( p = 0.0005), and higher plasma triglyceride levels ( p = 0.009) than did patients without steatosis. We report a significant association between palmitic acid (16:0), palmitoleic acid (16:1n-7) concentrations and ratio of monounsaturated to saturated fatty acid (palmitoleic acid to palmitic acid) and higher liver fat content. Total polyunsaturated fatty acid (PUFA), homo-gamma-linolenic acid (20:3n-6), docosahexaenoic acid (22:6n-3), and arachidonic acid (20:4 n-6) were associated with lower LFC. Conclusions Our data showed that an increased erythrocytes long-chain n-3 and n-6 fatty acids was associated with a lower prevalence of steatosis in patients with type 2 diabetes. These results suggest that n-3 and n-6 fatty acids supplementation could be a promising treatment for NAFLD in patients with type 2 diabetes.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Dietary Fats - administration &amp; dosage</subject><subject>Dietary Supplements</subject><subject>Endocrine pancreas. 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Impaired glucose tolerance</topic><topic>Dietary Fats - administration &amp; dosage</topic><topic>Dietary Supplements</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Erythrocytes - chemistry</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fatty acid composition</topic><topic>Fatty Acids, Monounsaturated - analysis</topic><topic>Fatty Acids, Monounsaturated - metabolism</topic><topic>Fatty Acids, Omega-3 - administration &amp; dosage</topic><topic>Fatty Acids, Omega-3 - blood</topic><topic>Fatty Acids, Omega-6 - administration &amp; dosage</topic><topic>Fatty Acids, Omega-6 - blood</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - physiopathology</topic><topic>Fatty Liver - prevention &amp; control</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Although dietary fat contributes substantially to the accumulation of liver fat, the role of individual fatty acids in this accumulation is unclear. Objective In this study, we set out to determine whether liver fat content (LFC), was associated with red blood cell fatty acid (RBC-FA) composition in people with type 2 diabetes. Design, settings, and participants One hundred and sixty-two type 2 diabetic patients were included in this study. LFC was measured using1 H-MR Spectroscopy. RBC-FA composition was measured by gas chromatography. Results One hundred and nine (67.2%) patients had steatosis. Patients with steatosis had a higher BMI ( p = 0.0005), and higher plasma triglyceride levels ( p = 0.009) than did patients without steatosis. We report a significant association between palmitic acid (16:0), palmitoleic acid (16:1n-7) concentrations and ratio of monounsaturated to saturated fatty acid (palmitoleic acid to palmitic acid) and higher liver fat content. Total polyunsaturated fatty acid (PUFA), homo-gamma-linolenic acid (20:3n-6), docosahexaenoic acid (22:6n-3), and arachidonic acid (20:4 n-6) were associated with lower LFC. Conclusions Our data showed that an increased erythrocytes long-chain n-3 and n-6 fatty acids was associated with a lower prevalence of steatosis in patients with type 2 diabetes. These results suggest that n-3 and n-6 fatty acids supplementation could be a promising treatment for NAFLD in patients with type 2 diabetes.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>22209679</pmid><doi>10.1016/j.clnu.2011.12.007</doi><tpages>6</tpages></addata></record>
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identifier ISSN: 0261-5614
ispartof Clinical nutrition (Edinburgh, Scotland), 2012-08, Vol.31 (4), p.520-525
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subjects Aged
Biological and medical sciences
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Dietary Fats - administration & dosage
Dietary Supplements
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Erythrocytes - chemistry
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty acid composition
Fatty Acids, Monounsaturated - analysis
Fatty Acids, Monounsaturated - metabolism
Fatty Acids, Omega-3 - administration & dosage
Fatty Acids, Omega-3 - blood
Fatty Acids, Omega-6 - administration & dosage
Fatty Acids, Omega-6 - blood
Fatty Liver - complications
Fatty Liver - physiopathology
Fatty Liver - prevention & control
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Humans
Male
Medical sciences
Middle Aged
Non-alcoholic Fatty Liver Disease
Palmitic Acid - analysis
Palmitic Acid - metabolism
Prevalence
Prospective Studies
PUFA
Steatosis
Triglycerides - blood
Type 2 diabetes
Vertebrates: anatomy and physiology, studies on body, several organs or systems
title Increased erythrocytes n-3 and n-6 polyunsaturated fatty acids is significantly associated with a lower prevalence of steatosis in patients with type 2 diabetes
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