Profuse sialorrhea in a case of anti N -methyl- d -aspartate receptor (NMDAR) encephalitis

Despite the severity of the disorder, patients often recovered after tumor removal and immunotherapy, suggesting an immune-mediated pathogenesis.2 Case report A 29-year-old female with no medical or psychiatric history presented to the emergency department of a different Hospital with gradually wors...

Full description

Saved in:
Bibliographic Details
Published in:Clinical neurology and neurosurgery 2012-09, Vol.114 (7), p.1066-1069
Main Authors: Salazar, R, James, E, Elsayed, M, Varelas, P, Bartscher, J, Corry, J, Abdelhak, T
Format: Article
Language:English
Subjects:
Adult
Anti N-methyl-d-aspartate receptor encephalitis
Anti-N-Methyl-D-Aspartate Receptor Encephalitis - complications
Anti-N-Methyl-D-Aspartate Receptor Encephalitis - psychology
Autoantibodies - analysis
Autoimmune diseases
Biological and medical sciences
Brain - pathology
Depression - etiology
Electroencephalography
Female
Gait Disorders, Neurologic - etiology
Hallucinations - etiology
Humans
Lupus
Magnetic Resonance Imaging
Medical sciences
Medical treatment
Neurology
Neurosurgery
Ovarian Neoplasms - pathology
Receptors, N-Methyl-D-Aspartate - immunology
Sialorrhea
Sialorrhea - etiology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Teratoma - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite the severity of the disorder, patients often recovered after tumor removal and immunotherapy, suggesting an immune-mediated pathogenesis.2 Case report A 29-year-old female with no medical or psychiatric history presented to the emergency department of a different Hospital with gradually worsening depression and hallucinations. [...]the patient received a total of 300 units of Onabotulinum toxin injections in selected bilateral upper extremities muscles. There are only anecdotal case reports of spontaneous recovery without surgical resection of the associated tumor [6].4 Conclusion This case underscores the importance of a high index of suspicion for NMDAR encephalitis even in case of atypical features such as profuse sialorrhea. [...]clinical practitioners should entertain the diagnosis of anti-NMDAR encephalitis, when a patient exhibits orofacial dyskinesia and profuse sialorrhea.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2012.02.011