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Relapsing Polychondritis in the Department of Defense Population and Review of the Literature

Objective The objective of this study was to characterize the clinical features of relapsing polychondritis (RPC) within the Department of Defense beneficiary population and determine the utility of echocardiography, imaging studies, and pulmonary function testing for diagnosis and monitoring diseas...

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Published in:Seminars in arthritis and rheumatism 2012-08, Vol.42 (1), p.70-83
Main Authors: Mathew, Stephanie D., DO, Battafarano, Daniel F., DO, FACP, FACR, Morris, Michael J., MD, FACP, FCCP
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description Objective The objective of this study was to characterize the clinical features of relapsing polychondritis (RPC) within the Department of Defense beneficiary population and determine the utility of echocardiography, imaging studies, and pulmonary function testing for diagnosis and monitoring disease. Methods We performed a retrospective Electronic Medical Record chart review of all patients diagnosed with RPC within the Department of Defense between January 2004 and December 2009. Results Thirty patients met McAdam's diagnostic criteria and an additional 13 met our criteria for partial RPC. Auricular chondritis (88%), inflammatory eye disease (57%), and arthritis (60%) were the most common clinical manifestations. Pulmonary involvement was seen in 16 (37%) patients. Methotrexate (42%) and corticosteroids (21%) were the most conventional therapies. Thirty (70%) patients had pulmonary function tests with flow volume loop abnormalities observed in 33%. Chest computed tomography was performed in 63%, with abnormalities in 48%. Abnormalities on echocardiography were observed in 12 of 25 (48%) patients. Conclusions The incidence, demographic data, and organ involvement in our RPC patients were similar to previous studies. The diagnosis of RPC was determined primarily on physical examination and symptom-driven diagnostic testing. There was no notable pattern by rheumatologists for monitoring the progression of tracheobronchial tree or large vessel involvement. Interpreting flow volume loops is recommended with pulmonary function testing to detect early laryngotracheal involvement. Computed tomography of the chest is also recommended to monitor for vascular and tracheobronchial tree involvement.
doi_str_mv 10.1016/j.semarthrit.2011.12.007
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Methods We performed a retrospective Electronic Medical Record chart review of all patients diagnosed with RPC within the Department of Defense between January 2004 and December 2009. Results Thirty patients met McAdam's diagnostic criteria and an additional 13 met our criteria for partial RPC. Auricular chondritis (88%), inflammatory eye disease (57%), and arthritis (60%) were the most common clinical manifestations. Pulmonary involvement was seen in 16 (37%) patients. Methotrexate (42%) and corticosteroids (21%) were the most conventional therapies. Thirty (70%) patients had pulmonary function tests with flow volume loop abnormalities observed in 33%. Chest computed tomography was performed in 63%, with abnormalities in 48%. Abnormalities on echocardiography were observed in 12 of 25 (48%) patients. Conclusions The incidence, demographic data, and organ involvement in our RPC patients were similar to previous studies. The diagnosis of RPC was determined primarily on physical examination and symptom-driven diagnostic testing. There was no notable pattern by rheumatologists for monitoring the progression of tracheobronchial tree or large vessel involvement. Interpreting flow volume loops is recommended with pulmonary function testing to detect early laryngotracheal involvement. Computed tomography of the chest is also recommended to monitor for vascular and tracheobronchial tree involvement.</description><identifier>ISSN: 0049-0172</identifier><identifier>EISSN: 1532-866X</identifier><identifier>DOI: 10.1016/j.semarthrit.2011.12.007</identifier><identifier>PMID: 22417894</identifier><identifier>CODEN: SAHRBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthritis - etiology ; Arthritis - pathology ; Biological and medical sciences ; Disease Progression ; Diseases of the osteoarticular system ; Ear Cartilage - pathology ; Female ; Glucocorticoids - therapeutic use ; Humans ; Immunosuppressive Agents - therapeutic use ; Inflammatory joint diseases ; Lung Diseases - etiology ; Lung Diseases - pathology ; Lung Diseases - physiopathology ; Male ; Medical sciences ; Methotrexate - therapeutic use ; Middle Aged ; Military Medicine ; Military Personnel ; Miscellaneous. 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Methods We performed a retrospective Electronic Medical Record chart review of all patients diagnosed with RPC within the Department of Defense between January 2004 and December 2009. Results Thirty patients met McAdam's diagnostic criteria and an additional 13 met our criteria for partial RPC. Auricular chondritis (88%), inflammatory eye disease (57%), and arthritis (60%) were the most common clinical manifestations. Pulmonary involvement was seen in 16 (37%) patients. Methotrexate (42%) and corticosteroids (21%) were the most conventional therapies. Thirty (70%) patients had pulmonary function tests with flow volume loop abnormalities observed in 33%. Chest computed tomography was performed in 63%, with abnormalities in 48%. Abnormalities on echocardiography were observed in 12 of 25 (48%) patients. Conclusions The incidence, demographic data, and organ involvement in our RPC patients were similar to previous studies. The diagnosis of RPC was determined primarily on physical examination and symptom-driven diagnostic testing. There was no notable pattern by rheumatologists for monitoring the progression of tracheobronchial tree or large vessel involvement. Interpreting flow volume loops is recommended with pulmonary function testing to detect early laryngotracheal involvement. Computed tomography of the chest is also recommended to monitor for vascular and tracheobronchial tree involvement.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis - etiology</subject><subject>Arthritis - pathology</subject><subject>Biological and medical sciences</subject><subject>Disease Progression</subject><subject>Diseases of the osteoarticular system</subject><subject>Ear Cartilage - pathology</subject><subject>Female</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Inflammatory joint diseases</subject><subject>Lung Diseases - etiology</subject><subject>Lung Diseases - pathology</subject><subject>Lung Diseases - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methotrexate - therapeutic use</subject><subject>Middle Aged</subject><subject>Military Medicine</subject><subject>Military Personnel</subject><subject>Miscellaneous. 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The diagnosis of RPC was determined primarily on physical examination and symptom-driven diagnostic testing. There was no notable pattern by rheumatologists for monitoring the progression of tracheobronchial tree or large vessel involvement. Interpreting flow volume loops is recommended with pulmonary function testing to detect early laryngotracheal involvement. Computed tomography of the chest is also recommended to monitor for vascular and tracheobronchial tree involvement.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22417894</pmid><doi>10.1016/j.semarthrit.2011.12.007</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Aged
Aged, 80 and over
Arthritis - etiology
Arthritis - pathology
Biological and medical sciences
Disease Progression
Diseases of the osteoarticular system
Ear Cartilage - pathology
Female
Glucocorticoids - therapeutic use
Humans
Immunosuppressive Agents - therapeutic use
Inflammatory joint diseases
Lung Diseases - etiology
Lung Diseases - pathology
Lung Diseases - physiopathology
Male
Medical sciences
Methotrexate - therapeutic use
Middle Aged
Military Medicine
Military Personnel
Miscellaneous. Osteoarticular involvement in other diseases
Polychondrities
Polychondritis, Relapsing - complications
Polychondritis, Relapsing - diagnosis
Polychondritis, Relapsing - drug therapy
Polychondritis, Relapsing - physiopathology
Radiography, Thoracic
Relapsing polychondrities
Respiratory Function Tests
Retrospective Studies
Rheumatology
Scleritis - etiology
Scleritis - pathology
Spirometry
United States
United States Department of Defense
Young Adult
title Relapsing Polychondritis in the Department of Defense Population and Review of the Literature
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