Cellular solitary fibrous tumor (hemangiopericytoma) with anaplasia at cerebellopontine angle—A case report

Cellular solitary fibrous tumor is currently considered a synonym for hemangiopericytoma, as it became increasingly clear that the morphological and immunohistochemical features that separate these two entities have become tenuous, and evidence for a unifying concept has emerged. Furthermore, as no...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2012-08, Vol.208 (8), p.493-496
Main Authors: Zeng, Jianying, Ogera, Patricia, Benardete, Ethan A., Nicastri, Anthony D., Rao, Chandrakant
Format: Article
Language:English
Subjects:
Anaplasia
Biomarkers, Tumor - metabolism
Cell Nucleus - pathology
Cerebellar Neoplasms - metabolism
Cerebellar Neoplasms - pathology
Cerebellar Neoplasms - surgery
Cerebellopontine angle
Cerebellopontine Angle - pathology
Factor XIIIa - metabolism
Hemangiopericytoma
Hemangiopericytoma - metabolism
Hemangiopericytoma - pathology
Hemangiopericytoma - surgery
Humans
Magnetic Resonance Imaging
Male
Mitosis
Solitary fibrous tumor
Treatment Outcome
Young Adult
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Summary:Cellular solitary fibrous tumor is currently considered a synonym for hemangiopericytoma, as it became increasingly clear that the morphological and immunohistochemical features that separate these two entities have become tenuous, and evidence for a unifying concept has emerged. Furthermore, as no evidence of pericytic differentiation is given in most cases of hemangiopericytoma, this diagnostic term is waning in popularity. We present here a case of cellular solitary fibrous tumor in a 22-year-old man. Neuroimaging revealed a right cerebellopontine angle tumor. Most of the tumor was cellular although some less cellular areas were seen. Sinusoidally dilated large vessels, including staghorn type, were seen. Nuclear pleomorphism and increased mitotic activity (5 mitosis/10 high power field) were regarded as evidence of anaplasia. Diffuse CD34 immunoreactivity and focal positivity for Factor XIIIa were seen in the tumor, which was negative for EMA and S100. The tumor also displayed rich reticulin network. Solitary fibrous tumor at cerebellopontine angle is rare, and 20 such cases (five reported as hemangiopericytoma) have been reported in the English literature.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2012.04.008