Gastrointestinal stromal tumors: prognostic factors and therapeutic implications

Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the digestive tract. They have recently been recognized as a separate nosological entity and the literature on these stromal tumors has rapidly expanded. The surgical records of 50 patients with primary GISTs treated...

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Bibliographic Details
Published in:Tumori 2012-05, Vol.98 (3), p.351-356
Main Authors: Rosa, Fausto, Alfieri, Sergio, Tortorelli, Antonio Pio, Di Miceli, Dario, Papa, Valerio, Ricci, Riccardo, Doglietto, Giovanni Battista
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Antineoplastic Agents - therapeutic use
Chemotherapy, Adjuvant
Digestive System Surgical Procedures - adverse effects
Digestive System Surgical Procedures - methods
Disease-Free Survival
Drug Resistance, Neoplasm
Female
Follow-Up Studies
Gastrointestinal Neoplasms - diagnosis
Gastrointestinal Neoplasms - drug therapy
Gastrointestinal Neoplasms - mortality
Gastrointestinal Neoplasms - pathology
Gastrointestinal Neoplasms - surgery
Gastrointestinal Neoplasms - therapy
Gastrointestinal Stromal Tumors - diagnosis
Gastrointestinal Stromal Tumors - drug therapy
Gastrointestinal Stromal Tumors - mortality
Gastrointestinal Stromal Tumors - pathology
Gastrointestinal Stromal Tumors - surgery
Gastrointestinal Stromal Tumors - therapy
Humans
Kaplan-Meier Estimate
Male
Medical Records
Middle Aged
Molecular Targeted Therapy - methods
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - therapy
Predictive Value of Tests
Prognosis
Recurrence
Retrospective Studies
Risk Assessment
Risk Factors
Treatment Outcome
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Summary:Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the digestive tract. They have recently been recognized as a separate nosological entity and the literature on these stromal tumors has rapidly expanded. The surgical records of 50 patients with primary GISTs treated at the Digestive Surgery Department of the Catholic University of Rome from January 1993 to December 2010 were reviewed and the prognostic factors were analyzed. Surgery was performed in all patients with curative intent. The median age at presentation was 66.5 years (range, 28-81). Adjuvant therapy was administered in 26 (52%) cases. Median follow-up was 71 months (range, 5-208). There was an 8% recurrence rate. The actuarial 5-year overall and disease-free survival rates were 66.3% and 57.2%, respectively. High mitotic rate (P
ISSN:2038-2529
DOI:10.1700/1125.12404