Carotid intima media thickness, brachial flow mediated dilation and previous history of gestational diabetes mellitus

Aim:  Gestational diabetes mellitus (GDM) is a common pregnancy condition with long‐term complications. We examined the association between inflammatory mediators and early atherosclerosis process by measuring the flow mediated dilatation (FMD) of brachial artery and carotid intima media thickness (...

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Published in:The journal of obstetrics and gynaecology research 2012-08, Vol.38 (8), p.1057-1063
Main Authors: Fakhrzadeh, Hossein, Alatab, Sudabeh, Sharifi, Farshad, Mirarefein, Mojde, Badamchizadeh, Zohreh, Ghaderpanahi, Maryam, Hashemi Taheri, Amir Pejman, Larijani, Bagher
Format: Article
Language:English
Subjects:
Adult
atherosclerosis
Atherosclerosis - etiology
Brachial Artery - physiopathology
Carotid Intima-Media Thickness
Case-Control Studies
Diabetes, Gestational - physiopathology
Female
Humans
inflammation
Pregnancy
ultrasound diagnosis
Vasodilation
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Summary:Aim:  Gestational diabetes mellitus (GDM) is a common pregnancy condition with long‐term complications. We examined the association between inflammatory mediators and early atherosclerosis process by measuring the flow mediated dilatation (FMD) of brachial artery and carotid intima media thickness (CIMT) in women with previous GDM (pGDM). Material and Methods:  Women with and without pGDM with an average of 4 years following the indexed pregnancy, participated in this study. Serum levels of IL‐6, hs‐CRP, adiponectin, homocystein and other biomedical parameters were measured. The existence of early atherogenesis process was evaluated by measuring CIMT and FMD. Results:  HOMA‐IR and insulin were significantly higher in women with pGDM. Women with pGDM had slightly higher CIMT and significantly lower percent of brachial FMD. FMD and CIMT, adjusted for age and blood pressure, showed the same pattern. FMD showed no correlation with biochemical or inflammatory markers. Conclusion:  Follow‐up of this group of women, who are at increased risk of cardiovascular disease, with FMD should be considered.
ISSN:1341-8076
1447-0756
DOI:10.1111/j.1447-0756.2011.01829.x