Inhibition of Gastrointestinal Lipolysis by Green Tea, Coffee, and Gomchui (Ligularia fischeri) Tea Polyphenols during Simulated Digestion

Green tea, coffee, and gomchui (Ligularia fischeri) tea, which are rich in polyphenols, may exhibit antiobesity effects by inhibiting pancreatic lipase. However, the bioavailability of some polyphenols is poor due to either degradation or absorption difficulties in the gastrointestinal tract, thus m...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2012-07, Vol.60 (29), p.7152-7157
Main Authors: Cha, Kwang Hyun, Song, Dae-Geun, Kim, Sang Min, Pan, Cheol-Ho
Format: Article
Language:English
Subjects:
absorption
Animals
Anti-Obesity Agents - pharmacology
Asteraceae - chemistry
Beverages
bioavailability
Biological Availability
Coffee - chemistry
Digestion
Enzyme Inhibitors - pharmacology
gastrointestinal system
Gastrointestinal Tract - enzymology
green tea
Humans
In Vitro Techniques
inhibitory concentration 50
isomers
Ligularia
Lipase - antagonists & inhibitors
lipolysis
Lipolysis - drug effects
Pancreas - enzymology
polyphenols
Polyphenols - pharmacokinetics
Polyphenols - pharmacology
Tea - chemistry
triacylglycerol lipase
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Summary:Green tea, coffee, and gomchui (Ligularia fischeri) tea, which are rich in polyphenols, may exhibit antiobesity effects by inhibiting pancreatic lipase. However, the bioavailability of some polyphenols is poor due to either degradation or absorption difficulties in the gastrointestinal tract, thus making their beneficial effects doubtful. This study was conducted to evaluate the inhibitory effect of three beverages on lipolysis and the contribution of their major polyphenols during simulated digestion. During simulated digestion, gomchui tea was the most potent at inhibiting gastrointestinal lipolysis, whereas green tea was the least potent. The strongest lipase inhibitor among purified major polyphenols was a green tea polyphenol, (−)-epigallocatechin gallate (EGCG, IC50 = 1.8 ± 0.57 μM), followed by di-O-caffeoylquinic acid isomers (DCQA, IC50 from 12.7 ± 4.5 to 40.4 ± 2.3 μM), which are gomchui tea polyphenols. However, the stability of DCQA was greater than that of EGCG when subjected to simulated digestion. Taken together, gomchui tea, which has DCQA as the major polyphenol, showed stronger lipolysis inhibitory activity during simulated digestion compared to both green tea and coffee.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf301047f