Myricetin Facilitates Potassium Currents and Inhibits Neuronal Activity of PVN Neurons

The effects of myricetin on hypothalamic paraventricular nucleus (PVN) neurons in rats were investigated. By whole-cell patch clamp detection in hypothalamic brain slices, we showed that the action potential frequency in type-I PVN neurons dose-dependently decreased after myricetin treatment. Furthe...

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Bibliographic Details
Published in:Neurochemical research 2012-07, Vol.37 (7), p.1450-1456
Main Authors: Ma, ZeGang, Liu, TianWei
Format: Article
Language:English
Subjects:
Action potential
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain slice preparation
Cadmium
Calcium
Cell Biology
Flavonoids - pharmacology
Humans
Hypothalamus
Male
Neurochemistry
Neurology
Neurons
Neurons - drug effects
Neurosciences
Original Paper
Paraventricular Hypothalamic Nucleus - cytology
Paraventricular Hypothalamic Nucleus - drug effects
Paraventricular nucleus
Patch-Clamp Techniques
Perfusion
Potassium Channels - drug effects
Potassium currents
Rats
Rats, Sprague-Dawley
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Summary:The effects of myricetin on hypothalamic paraventricular nucleus (PVN) neurons in rats were investigated. By whole-cell patch clamp detection in hypothalamic brain slices, we showed that the action potential frequency in type-I PVN neurons dose-dependently decreased after myricetin treatment. Further studies demonstrated that myricetin may enhance potassium currents and shifts the voltage-dependence of activation of potassium currents to more negative potentials by 6.07 mV. Using calcium free/cadmium perfusion solution could reverse myricetin-induced enhancement of potassium currents in PVN neurons. These results suggested that inhibition of hypothalamic PVN neurons by myricetin might be attributed to the enhancement of potassium currents.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-012-0732-2