Genetic variants of SDF-1 and CXCR4 genes in endometrial carcinoma

In this study, we aimed to investigate a possible association between the Stromal cell-derived factor-1 (SDF-1) and CXCR4 polymorphisms and the risk of developing endometrial carcinoma. SDF-1 3′A and CXCR4 gene polymorphisms was performed by polymerase chain reaction (PCR) and restriction fragment l...

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Bibliographic Details
Published in:Molecular biology reports 2012-02, Vol.39 (2), p.1225-1229
Main Authors: Cacina, Canan, Bulgurcuoglu-Kuran, Sibel, Iyibozkurt, Ahmet Cem, Yaylim-Eraltan, Ilhan, Cakmakoglu, Bedia
Format: Article
Language:English
Subjects:
Adult
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Carcinogenesis
Carcinoma
Chemokine CXCL12 - genetics
Chemokines
CXCR4 protein
DNA Primers - genetics
Endometrial cancer
Endometrial Neoplasms - epidemiology
Endometrial Neoplasms - genetics
Endometrium
Female
Gene polymorphism
Genetic Association Studies
Genetic diversity
Genetic Variation
Genotype
Histology
Humans
Life Sciences
Linkage Disequilibrium
Molecular biology
Morphology
Odds Ratio
Polymerase Chain Reaction
Polymorphism
Polymorphism, Restriction Fragment Length
Receptors, CXCR4 - genetics
Restriction fragment length polymorphism
Risk Factors
SDF-1 protein
Turkey - epidemiology
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Summary:In this study, we aimed to investigate a possible association between the Stromal cell-derived factor-1 (SDF-1) and CXCR4 polymorphisms and the risk of developing endometrial carcinoma. SDF-1 3′A and CXCR4 gene polymorphisms was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism in 139 healthy individuals and 113 patients with endometrial carcinoma. In our study groups SDF-1 3′A AA genotype frequency was higher in patients that of controls and individuals who had AA genotype showed a 2.6-fold increased risk for endometrial cancer. The carriers of CXCR4 T allele were higher in patients compared with controls and individuals who had TT genotype had a 2.5-fold high risk for endometrial carcinoma. Our finding suggest that there was no significant association between the (SDF-1) and CXCR4 polymorphisms and endometrium cancer risk. Further studies in a larger population are needed to better elucidate the role of (SDF-1) and CXCR4 gene polymorphisms in the risk of endometrial carcinogenesis. To the best of our knowledge, this is the first study to show such an association.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-011-0852-9