The amnesic effect of intra-central amygdala administration of a cannabinoid CB1 receptor agonist, WIN55,212-2, is mediated by a beta-1 noradrenergic system in rat

Highlights ► Post-training intra-CeA injections of WIN55,212-2 induced amnesia. ► Isoprenaline prevented while atenolol increased the impairing effect of WIN55,212-2. ► Atenolol prevented the improving effect of isoprenaline on WIN55,212-2 response. ► Adrenoceptors in the CeA are indirectly involved...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2012-06, Vol.212, p.77-85
Main Authors: Zarrindast, M.R, Ghiasvand, M, Rezayof, A, Ahmadi, S
Format: Article
Language:English
Subjects:
Amnesia
Amnesia - chemically induced
Amnesia - metabolism
Amnesia - physiopathology
Amygdala
Amygdala - drug effects
Amygdala - physiology
Animals
Atenolol
Benzoxazines - pharmacology
Biological and medical sciences
Cannabinoid CB1 receptors
cannabinoid receptor
Cannabinoid Receptor Modulators - pharmacology
central amygdala
Drugs
Fundamental and applied biological sciences. Psychology
isoprenaline
Male
Medical sciences
Memory
Memory - drug effects
Memory - physiology
Morpholines - pharmacology
Naphthalenes - pharmacology
Nervous system
Neurology
Neuropharmacology
Norepinephrine
Pharmacology. Drug treatments
Psychodysleptics: hallucinogen
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
rat
Rats
Rats, Wistar
Receptor, Cannabinoid, CB1 - agonists
Receptors, Adrenergic, beta-1 - physiology
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Post-training intra-CeA injections of WIN55,212-2 induced amnesia. ► Isoprenaline prevented while atenolol increased the impairing effect of WIN55,212-2. ► Atenolol prevented the improving effect of isoprenaline on WIN55,212-2 response. ► Adrenoceptors in the CeA are indirectly involved in amnesia induced by WIN55,212-2.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.04.008