Sex difference and the role of leptin in the association between high-sensitivity C-reactive protein and adiposity in two different populations

Elevated high-sensitivity C-reactive protein (hs-CRP) concentration is associated with an increased risk of cardiovascular disease but this association seems to be largely mediated via conventional cardiovascular risk factors. In particular, the association between hs-CRP and obesity has been extens...

Full description

Saved in:
Bibliographic Details
Published in:European journal of epidemiology 2012-05, Vol.27 (5), p.379-384
Main Authors: Rossi, Isabelle Anne, Bochud, Murielle, Bovet, Pascal, Paccaud, Fred, Waeber, Gérard, Vollenweider, Peter, Taffé, Patrick
Format: Article
Language:English
Subjects:
Adiposity
Adiposity - physiology
Adult
African Continental Ancestry Group
Alcohol drinking
Biological and medical sciences
Biomarkers - blood
Body fat
Body Mass Index
C-Reactive Protein - metabolism
Cardiology
Cardiovascular diseases
Cigarette smoking
Epidemiology
European Continental Ancestry Group
Exercise
Female
Gender
Gender differences
General aspects
Health risks
Health Surveys
Hormones
Humans
Infectious Diseases
Leptin - blood
Male
Mass
Medical sciences
Medicine
Medicine & Public Health
Men
Metabolic diseases
Middle Aged
Miscellaneous
Models, Statistical
Multivariate Analysis
OBESITY
Oncology
Population studies
Proteins
Public Health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Regression Analysis
Risk factors
Sex Factors
Sex linked differences
Seychelles
Switzerland
White people
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Elevated high-sensitivity C-reactive protein (hs-CRP) concentration is associated with an increased risk of cardiovascular disease but this association seems to be largely mediated via conventional cardiovascular risk factors. In particular, the association between hs-CRP and obesity has been extensively demonstrated and correlations are stronger in women than men. We used fractional polynomials—a method that allows flexible modeling of non linear relations—to investigate the dose/response mathematical relationship between hs-CRP and several indicators of adiposity in Caucasians (Switzerland) and Africans (Seychelles) surveyed in two population-based studies. This relationship was non-linear exhibiting a steeper slope for low levels of hs-CRP and a higher level in women. The observed sex difference in the relationship between hs-CRP and adiposity almost disappeared upon adjustment for leptin, suggesting that these sex differences might be partially mediated, by leptin. All these relationship were similar in Caucasians and Africans. This is the first report on a non-linear relation, stratified by gender, between hs-CRP and adiposity.
ISSN:0393-2990
1573-7284
DOI:10.1007/s10654-012-9671-0