Type 1 immune response in progressive multiple sclerosis

Abstract The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+ T-bet+ and CD8+ T-bet+ T ce...

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Bibliographic Details
Published in:Journal of neuroimmunology 2012-08, Vol.249 (1), p.112-116
Main Authors: Frisullo, Giovanni, Plantone, Domenico, Marti, Alessandro, Iorio, Raffaele, Damato, Valentina, Nociti, Viviana, Patanella, Agata Katia, Bianco, Assunta, Batocchi, Anna Paola
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Disease Progression
Female
Helper cells
Humans
Lymphocytes B
Lymphocytes T
Male
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Chronic Progressive - immunology
Neurology
PPMS
Severity of Illness Index
SPMS
T-bet
T-Box Domain Proteins - immunology
T-Lymphocyte Subsets - immunology
Transcription factor
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Summary:Abstract The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4+ T-bet+ and CD8+ T-bet+ T cells in SPMS and PPMS than in remitting–relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4+ T-bet+ or CD8+ T-bet+ T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2012.04.019