Accumulation of SNAP25 in mouse gustatory and somatosensory cortices in response to food and chemical stimulation

• Published in: Neuroscience 2012-08, Vol.218, p.326-334
• Main Authors: Kawakami, S, Ohmoto, M, Itoh, S, Yuasa, R, Inagaki, H, Nishimura, E, Ito, T, Misaka, T
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Blotting, Western; Capsaicin; Cerebral Cortex - metabolism; Cortex; Cortex (somatosensory); Eating - physiology; Food intake; food signal; Fundamental and applied biological sciences. Psychology; gustatory cortex; Immunohistochemistry; Immunoreactivity; Mice; Mice, Inbred C57BL; Milk; N-Ethylmaleimide-sensitive protein; Nervous system; Neurology; Neuronal Plasticity - physiology; Olfactory system and olfaction. Gustatory system and gustation; Oral cavity; Plasticity (developmental); Plasticity (neural); Plasticity (synaptic); Saccharin; SNAP receptors; SNAP-25 protein; SNAP25; somatosensory cortex; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Stimulation, Chemical; Synaptic transmission; Synaptosomal-Associated Protein 25 - biosynthesis; Tactile stimuli; Taste; Taste Perception - physiology; Vertebrates: nervous system and sense organs; Weaning; weaning period
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.05.045

Highlights ► Effect of food intake on mouse brain was investigated. ► SNAP25 in the cerebral cortex increased after mice began intake of solid food. ► Saccharin or capsaicin signals also increased SNAP25 immunoreactivity. ► SNAP25 signals predominantly appeared in the gustatory and somatosensory cortices.