The effect of neonatal N-methyl-d-aspartate receptor blockade on exploratory and anxiety-like behaviors in adult BALB/c and C57BL/6 mice

► NMDA receptors (NMDAR) play an important role in brain developmental processes. ► The role of hereditary factors in NMDAR blockade-induced behavioral responses is unknown. ► However, hereditary factors may be involved in neonatal NMDAR blockade-induced responses. N-methyl-d-aspartate (NMDA) recept...

Full description

Saved in:
Bibliographic Details
Published in:Behavioural brain research 2012-07, Vol.233 (1), p.157-161
Main Authors: Akillioglu, Kubra, Binokay, Secil, Kocahan, Sayad
Format: Article
Language:English
Subjects:
Age Factors
Analysis of Variance
Animals
Animals, Newborn
Anxiety
Anxiety - chemically induced
Anxiety - physiopathology
Anxiety-like
BALB/C
Birth
Body Weight - drug effects
Brain
C57BL/6
Critical period
Disease Models, Animal
Dizocilpine Maleate - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
Exploratory behavior
Exploratory Behavior - drug effects
Exploratory Behavior - physiology
Exploratory locomotion
Glutamic acid receptors
Glutamic acid receptors (ionotropic)
Locomotion
Locomotor activity
Maze Learning - drug effects
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
MK-801
N-Methyl-D-aspartic acid receptors
Neonates
NMDA receptor
Reaction Time
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - metabolism
Species Specificity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:► NMDA receptors (NMDAR) play an important role in brain developmental processes. ► The role of hereditary factors in NMDAR blockade-induced behavioral responses is unknown. ► However, hereditary factors may be involved in neonatal NMDAR blockade-induced responses. N-methyl-d-aspartate (NMDA) receptors play an important role in brain maturation and developmental processes. In our study, we evaluated the effects of neonatal NMDA receptor blockade on exploratory locomotion and anxiety-like behaviors of adult BALB/c and C57BL/6 mice. In this study, NMDA receptor hypofunction was induced 7–10 days after birth using MK-801 in BALB/c and C57BL/6 mice (0.25mg/kg twice a day for 4 days via intraperitoneal injection). The open-field (OF) and elevated plus maze (EPM) tests were used to evaluate exploratory locomotion and anxiety-like behaviors. In the OF, BALB/c mice spent less time in the center of the field (p
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2012.04.041