Redox-responsive regulation of denitrification genes in Brucella

Summary Brucella strains encounter oxygen deprivation during their intracellular replication in host cells, and the capacity of these bacteria to utilize NO3 as an alternative electron acceptor for respiration plays an important role in their successful adaption to their intracellular niche. In this...

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Bibliographic Details
Published in:Molecular microbiology 2012-07, Vol.85 (1), p.5-7
Main Authors: Roop II, R. Martin, Caswell, Clayton C.
Format: Article
Language:English
Subjects:
Animals
Bacteriology
Biological and medical sciences
Brucella abortus
Brucella abortus - genetics
Denitrification
Fundamental and applied biological sciences. Psychology
Gene expression
Gram-negative bacteria
Histidine Kinase
Hypoxia
Microbiology
Miscellaneous
Nitrogen - metabolism
Oxygen - metabolism
Protein Kinases - metabolism
Respiration
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Summary:Summary Brucella strains encounter oxygen deprivation during their intracellular replication in host cells, and the capacity of these bacteria to utilize NO3 as an alternative electron acceptor for respiration plays an important role in their successful adaption to their intracellular niche. In this issue of Molecular Microbiology, Carrica et al (2012). report that NtrY and NtrX comprise a redox‐responsive two‐component regulator in Brucella abortus 2308 that responds to decreasing levels of O2 and induces the expression of this strain's denitrification genes. Thus, NtrYX joins the increasing number of genetic regulators that contribute to the metabolic versatility required for the virulence of Brucella strains in their mammalian hosts.
ISSN:0950-382X
1365-2958
DOI:10.1111/j.1365-2958.2012.08096.x