Distribution and localisation of Gα proteins in the rostral ventrolateral medulla of normotensive and hypertensive rats: Focus on catecholaminergic neurons

• Published in: Neuroscience 2012-08, Vol.218, p.20-34
• Main Authors: Parker, L.M, Tallapragada, V.J, Kumar, N.N, Goodchild, A.K
• Format: Article
• Language: English
• Subjects: Adenylate cyclase; Animals; Biological and medical sciences; Blood pressure; Blood Pressure - physiology; Brain stem; Catecholamines - metabolism; Fundamental and applied biological sciences. Psychology; G protein-coupled receptors; G-proteins; Gene expression; GTP-Binding Protein alpha Subunits - metabolism; Guanine nucleotide-binding protein; Homeostasis; Immunohistochemistry; In Situ Hybridization; Medulla oblongata; Medulla Oblongata - metabolism; Nervous system; Neurology; Neurons; Neurons - metabolism; Polymerase chain reaction; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reflexes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; rostral C1; rostral ventrolateral medulla; Signal Transduction - physiology; spontaneously hypertensive rat; Vertebrates: nervous system and sense organs
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.05.037

Graphical abstract Highlights ► GPCR signalling via adenylyl cyclase is prominent in the RVLM. ► Gα mRNA abundance is Gαs > Gαi2 > Gαo > Gαq > GαL > Gα11 > Gαi3 > Gαi1 > Gα12 > Gα13 in RVLM. ► Multiple Gα mRNAs reflect a diversity of GPCR inputs to C1, A1 and A5 groups. ► Catecholaminergic groups in the ventral medulla express Gα mRNAs differentially. ► Gα mRNA distribution is similar in the RVLM of SD, SHR and WKY except Gαs.