Cardiac remodelling of Atlantic halibut Hippoglossus hippoglossus induced by experimental anaemia with phenylhydrazine

Phenylhydrazine injections (0·3 mg kg−1, followed by a second injection of 0·1 mg kg−1 7 days later) induced a reproducible and stable anaemia in Atlantic halibut Hippoglossus hippoglossus, reducing the haematocrit and haemoglobin by 70·0 and 75·5%, respectively, over 3 weeks. There were no changes...

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Bibliographic Details
Published in:Journal of fish biology 2012-07, Vol.81 (1), p.335-344
Main Authors: Powell, M. D., Burke, M. S., Dahle, D.
Format: Article
Language:English
Subjects:
Anemia - chemically induced
Animals
blood chemistry
Dimethyl Sulfoxide
Flounder - anatomy & histology
haematocrit
Heart - drug effects
Heart - physiopathology
Hematocrit
Hemoglobins - analysis
Hippoglossus hippoglossus
hypertrophy
Marine
Phenylhydrazines - adverse effects
pleuronectiformes
Ventricular Remodeling - drug effects
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Summary:Phenylhydrazine injections (0·3 mg kg−1, followed by a second injection of 0·1 mg kg−1 7 days later) induced a reproducible and stable anaemia in Atlantic halibut Hippoglossus hippoglossus, reducing the haematocrit and haemoglobin by 70·0 and 75·5%, respectively, over 3 weeks. There were no changes in blood electrolyte or lactate concentrations, although anaemic fish showed a 37·5 and 33·0% increase in cardiac somatic index and ventricular somatic index, respectively, compared with dimethyl sulphur oxide (DMSO) and saline vehicle controls. Changes in cardiac somatic indices did not correlate with the ratio of ventricular length:height and length:width did correlate with haematocrit and haemoglobin indicating that changes in cardiac shape may occur as a function of anaemic hypoxemia.
ISSN:0022-1112
1095-8649
DOI:10.1111/j.1095-8649.2012.03327.x