CCR9+ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice

Highlights ► Murine small intestine expressed a high amount of CCL25. ► Murine small intestine retained a large number of CCR9+ pDC. ► ccr9−/− × rag-2−/− mice transferred with CD4+ CD45RBhigh T cells developed ileitis. ► CCR9+ pDCs may play an important role in suppression of intestinal inflammation...

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Bibliographic Details
Published in:Immunology letters 2012-08, Vol.146 (1), p.64-69
Main Authors: Mizuno, Shinta, Kanai, Takanori, Mikami, Yohei, Sujino, Tomohisa, Ono, Yuichi, Hayashi, Atsushi, Handa, Tango, Matsumoto, Atsuhiro, Nakamoto, Nobuhiro, Matsuoka, Katsuyoshi, Hisamatsu, Tadakazu, Takaishi, Hiromasa, Hibi, Toshifumi
Format: Article
Language:English
Subjects:
Adoptive Transfer
Allergy and Immunology
Animals
Antigens, CD - genetics
Antigens, CD - immunology
CCR9/CCL25
Cell Movement
Chemokines, CC - genetics
Chemokines, CC - immunology
Colitis
Colitis - complications
Colitis - genetics
Colitis - immunology
Colitis - pathology
Colon - immunology
Colon - pathology
Crosses, Genetic
Dendritic Cells - immunology
Dendritic Cells - pathology
DNA-Binding Proteins - deficiency
DNA-Binding Proteins - genetics
DNA-Binding Proteins - immunology
Ileitis
Ileitis - complications
Ileitis - genetics
Ileitis - immunology
Ileitis - pathology
Immune regulation
Inflammation - complications
Inflammation - genetics
Inflammation - immunology
Inflammation - pathology
Intestine, Small - immunology
Intestine, Small - pathology
Mice
Organ Specificity
Plasmacytoid dendritic cells
Receptors, CCR - deficiency
Receptors, CCR - genetics
Receptors, CCR - immunology
Th1 Cells - immunology
Th1 Cells - pathology
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Summary:Highlights ► Murine small intestine expressed a high amount of CCL25. ► Murine small intestine retained a large number of CCR9+ pDC. ► ccr9−/− × rag-2−/− mice transferred with CD4+ CD45RBhigh T cells developed ileitis. ► CCR9+ pDCs may play an important role in suppression of intestinal inflammation.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2012.05.001