new sesquiterpene lactone from Elephantopus tomentosus

A new sesquiterpene lactone, named tomenphantopin H (1), together with two known germacranolides, 2β-methoxy-2-deethoxy-8-O-deacylphantomolin-8-O-tiglinate (2) and 2-deethoxy-2-hydroxyphantomolin (3), was isolated from the whole plant of Elephantopus tomentosus Linn. The new compound was completely...

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Bibliographic Details
Published in:Journal of asian natural products research 2012-07, Vol.14 (7), p.700-703
Main Authors: Wang, Bei, Mei, Wen-Li, Zeng, Yan-Bo, Guo, Zhi-Kai, Liu, Guo-Dao, Dai, Hao-Fu
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antibacterial activity
antibacterial properties
Asteraceae
Asteraceae - chemistry
Biological and medical sciences
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Elephantopus
Elephantopus tomentosus
General pharmacology
Herbivores
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Medical sciences
Microbial Sensitivity Tests
Molecular Structure
nuclear magnetic resonance spectroscopy
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
sesquiterpene lactone
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Sesquiterpenes, Germacrane - chemistry
Sesquiterpenes, Germacrane - isolation & purification
sesquiterpenoids
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Summary:A new sesquiterpene lactone, named tomenphantopin H (1), together with two known germacranolides, 2β-methoxy-2-deethoxy-8-O-deacylphantomolin-8-O-tiglinate (2) and 2-deethoxy-2-hydroxyphantomolin (3), was isolated from the whole plant of Elephantopus tomentosus Linn. The new compound was completely elucidated using a combination of 1D and 2D NMR techniques (COSY, HMQC, and HMBC) and HR-ESI-MS analyses. All compounds exhibited antibacterial activity.
ISSN:1477-2213
1028-6020
1477-2213
DOI:10.1080/10286020.2012.682153