Amygdalar excitatory/inhibitory circuits interacting with orexinergic neurons influence differentially feeding behaviors in hamsters

• Published in: Behavioural brain research 2012-09, Vol.234 (1), p.91-99
• Main Authors: Avolio, E., Alò, R., Mele, M., Carelli, A., Canonaco, A., Bucarelli, L., Canonaco, M.
• Format: Article
• Language: English
• Subjects: Amygdala; Amygdala - drug effects; Animals; Cricetinae; Drinking - drug effects; Feeding; Feeding Behavior - drug effects; GABA; GABA-A Receptor Agonists - pharmacology; Glutamate; Hamster; Hypothalamus - drug effects; Intracellular Signaling Peptides and Proteins - pharmacology; Neurons - drug effects; Neurons - metabolism; Neuropeptides - pharmacology; Orexin; Orexins
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2012.06.013

► Increased food consumption following infusion of hamster BlA with ORX-A. ► Treatment of CeA with ORX-B prevailed on water consumption. ► ORX-A/-B+NMDA/zolpidem increased or reduced eating/drinking behaviors, respectively. ► The same treatments accounted for up and down ORX-2R expression levels. ► ORX-A/B+combined treatment support new therapeutic bearings on psychiatric disorders. Recently, environmental stimuli on different neurobiological events, via participation of distinct amygdalar (AMY) ORXergic fibers have aroused wide interests in view of their ability to modify neuronal linked stressful and physiological homeostatic conditions. Results of the present study indicate that ORXergic (ORX-A/B) circuits of the facultative hibernating golden hamster (Mesocricetus auratus) central AMY (CeA) and basolateral AMY (BlA) nuclei constitute major sites of feeding behaviors. Indeed, hamsters after treatment of BlA with ORX-A frequently ingested greater quantities of food as compared to controls, while ORX-B in CeA induced a very (p