hGH and GHR Expression in Large Cell Neuroendocrine Carcinoma of the Colon and Rectum

Large cell neuroendocrine carcinoma (LCNEC) is an aggressive neoplasm with a low frequency of occurrence in the digestive tract. We present a series of eight patients diagnosed with LCNEC of the colon and rectum. Grossly, tumors were presented as endophytic/ulcerative, annular and polypoid masses, w...

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Bibliographic Details
Published in:Anticancer research 2012-08, Vol.32 (8), p.3377-3381
Main Authors: JUKIC, Zoran, LIMANI, Rine, LUCI, Lumturije Gashi, NIKIC, Vivian, MIJIC, August, TOMAS, Davor, KRUSLIN, Bozo
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Neuroendocrine - metabolism
Colonic Neoplasms - metabolism
Female
Growth Hormone - metabolism
Humans
Male
Medical sciences
Middle Aged
Receptors, Somatotropin - metabolism
Rectal Neoplasms - metabolism
Tumors
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Summary:Large cell neuroendocrine carcinoma (LCNEC) is an aggressive neoplasm with a low frequency of occurrence in the digestive tract. We present a series of eight patients diagnosed with LCNEC of the colon and rectum. Grossly, tumors were presented as endophytic/ulcerative, annular and polypoid masses, with a gray-white color and necrosis in most cases. Histologically, they were high-grade tumors composed of large cells of organoid, nesting, trabecular, rosette-like and palisading patterns, with a high mitotic rate. Tumors were immunoreactive for neuroendocrine markers, including chromogranin A (2/8), synaptophysin (7/8), and neuron-specific enolase (8/8). Moreover, we analyzed the expression of growth hormone (hGH) and growth hormone receptor (GHR) in colorectal LCNECs and six tumors were immunoreactive for hGH, while five tumors were immunoreactive for GHR. To our knowledge hGH and GHR expression has not been previously analyzed in colorectal LCNEC. Their overexpression suggests a role of hGH and GHR in the development of colorectal LCNEC.
ISSN:0250-7005
1791-7530