Novel multi walled carbon nanotubes/β-cyclodextrin based carbon paste electrode for flow injection potentiometric determination of piroxicam

• Published in: Talanta (Oxford) 2012-08, Vol.97, p.96-102
• Main Authors: Khaled, Elmorsy, Kamel, Manal S., Hassan, Hassan N.A., Haroun, Ahmed A., Youssef, Ahmed M., Aboul-Enein, Hassan Y.
• Format: Article
• Language: English
• Subjects: Analytical chemistry; beta-Cyclodextrins - chemistry; Carbon nanotubes; Carbon paste electrodes; Chemistry; Composite; Cyclodextrins; Electrochemical methods; Electrodes; Exact sciences and technology; Flow injection analysis; Flow Injection Analysis - instrumentation; Flow Injection Analysis - methods; Ionophores - chemistry; Nanotubes, Carbon - chemistry; Ointments; Pharmaceutical analysis; Piroxicam; Piroxicam - analysis; Piroxicam - chemistry; Potentiometry - instrumentation; Potentiometry - methods
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2012.04.001

A novel carbon paste electrode based on functionlized multi-walled carbon nanotubes/β-cyclodextrin composite (FMWCNTs/β-CD-CPE) is described for potentiometric determination of piroxicam (PXM). Improved sensitivity and selectivity was achieved by application of CDs as molecular host–guest recognition elements and MWCNTs. The electrochemical performance of carbon paste electrodes incroporated with FMWCNTs/β-CD composite was compared to those incroporated with MWCNTs and free CDs. Matrices compositions of each electrode are optimized on the basis of nature and content of the modifier, ionic sites and selected plasticizer. CPEs containing FMWCNTs/β-CD composite, hyamine (Hy) and 2-fluorophenyl 2-nitrophenyl ether (f-NPE) as electrode plasticizer, work satisfactory in the concentration range from 10−6 to 10−2molL−1 with Nernstain compliance (58.7±0.9mVdecade−1 activity) with fast response time of about 2s and exhibit adequate operational lifetime (16 weeks). The developed electrodes have been applied for the potentiometric determination of PXM in pharmaceutical formulation under batch and flow injection analysis (FIA). FIA allows the analysis of 120samplesh−1 with the advantage of simplicity, accuracy and automation feasibility. ► Multi-walled carbon nanotubes/β-cyclodextrin modified carbon paste electrode is constructed. ► Using of the nanocomposite improved the sensitivity, response time and lifetime. ► The developed sensors were applied for piroxicam determination in pharmaceutical formulations.