The diagnostic value of 18F-FDG-PET/CT in hematopoietic radiation toxicity: a Tibet minipig model

This study was undertaken to assess the diagnostic value of 2-[(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography with computed tomography ([(18)F]-FDG-PET/CT) in the detection of radiation toxicity in normal bone marrow using Tibet minipigs as a model. Eighteen Tibet minipigs were caged i...

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Bibliographic Details
Published in:Journal of radiation research 2012-07, Vol.53 (4), p.537-544
Main Authors: Chen, Chi, Yan, Li-Meng, Guo, Kun-Yuan, Wang, Yu-Jue, Zou, Fei, Gu, Wei-Wang, Tang, Hua, Li, Yan-Ling, Wu, Shao-Jie
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - cytology
Cell Survival
Dose-Response Relationship, Radiation
Fluorodeoxyglucose F18
Hematopoietic System - drug effects
Male
Particle Accelerators
Positron-Emission Tomography - methods
Radiopharmaceuticals
Swine
Swine, Miniature
Time Factors
Tomography, X-Ray Computed - methods
X-Rays
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Summary:This study was undertaken to assess the diagnostic value of 2-[(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography with computed tomography ([(18)F]-FDG-PET/CT) in the detection of radiation toxicity in normal bone marrow using Tibet minipigs as a model. Eighteen Tibet minipigs were caged in aseptic rooms and randomly divided into six groups. Five groups (n = 3/group) were irradiated with single doses of 2, 5, 8, 11 and 14 Gy of total body irradiation (TBI) using an 8-MV X-ray linear accelerator. These pigs were evaluated with [(18)F]-FDG-PET/CT, and their marrow nucleated cells were counted. The data were initially collected at 6, 24 and 72 h after treatment and were then collected on Days 5-60 post-TBI at 5-day intervals. At 24 and 72 h post-TBI, marrow standardized uptake value (SUV) data showed a dose-dependent decrease in the radiation dose range from 2-8 Gy. Upon long-term observation, SUV and marrow nucleated cell number in the 11-Gy and 14-Gy groups showed a continuous and marked reduction throughout the entire time course, while Kaplan-Meier curves of survival showed low survival. In contrast, the SUVs in the 2-, 5- and 8-Gy groups showed early transient increases followed by a decline from approximately 72 h through Days 5-15 and then normalized or maintained low levels through the endpoint; marrow nucleated cell number and survival curves showed approximately the same trend and higher survival, respectively. Our findings suggest that [(18)F]-FDG-PET/CT may be helpful in quickly assessing the absorbed doses and predicting the prognosis in patients.
ISSN:1349-9157
DOI:10.1093/jrr/rrs006