Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias

LR11/SorLA, a receptor interacting with CD87 on monocytes and macrophages, is highly expressed on human immature hematopoietic stem cells. However, it is unknown whether LR11 is expressed on premature leukemic cells, and whether the levels of circulating soluble LR11 (sLR11) shed from leukemic cells...

Full description

Saved in:
Bibliographic Details
Published in:Clinica chimica acta 2012-10, Vol.413 (19-20), p.1542-1548
Main Authors: Sakai, Shio, Nakaseko, Chiaki, Takeuchi, Masahiro, Ohwada, Chikako, Shimizu, Naomi, Tsukamoto, Shokichi, Kawaguchi, Takeharu, Jiang, Meizi, Sato, Yasunori, Ebinuma, Hiroyuki, Yokote, Koutaro, Iwama, Atsushi, Fukamachi, Isamu, Schneider, Wolfgang Johann, Saito, Yasushi, Bujo, Hideaki
Format: Article
Language:English
Subjects:
ALL
AML
Antineoplastic Agents - administration & dosage
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
CD87
Cell Line, Tumor
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Gene Expression
Humans
LDL-Receptor Related Proteins - blood
LDL-Receptor Related Proteins - genetics
Leukemia, Myeloid, Acute - blood
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
LR11/SorLA
Membrane Transport Proteins - blood
Membrane Transport Proteins - genetics
Monocyte
Monocytes - pathology
Monocytes - secretion
Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Real-Time Polymerase Chain Reaction
Remission Induction
Solubility
uPAR
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:LR11/SorLA, a receptor interacting with CD87 on monocytes and macrophages, is highly expressed on human immature hematopoietic stem cells. However, it is unknown whether LR11 is expressed on premature leukemic cells, and whether the levels of circulating soluble LR11 (sLR11) shed from leukemic cells correlate with disease state. The expression of LR11 on leucocytes and leukemic cells was examined by flow cytometry. Serum sLR11 levels were measured by ELISA in patients with various hematological diseases, including 43 acute myeloid leukemia (AML) and 23 acute lymphoblastic leukemia (ALL) patients. Data were subjected to statistical analysis for validation of sLR11 levels and patients' clinical data. LR11 is specifically expressed in monocytes, and surface levels on leukemic cells are highly induced in both AML and ALL. sLR11 levels of acute leukemia patients were significantly increased (P
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2012.06.025