Interactions of acid–base balance and hematocrit regulation during environmental respiratory gas challenges in developing chicken embryos ( Gallus gallus )

Highlights ► We used chick embryos as a unique model of acid–base and red blood cell regulation. ► Exposure to hypoxia resulted in metabolic acidosis with some difference among ages. ► Hypercapnia, hypercapnic hypoxia or hyperoxia resulted in respiratory acidosis. ► Increased Hct in 1-day hypoxia wa...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2012-08, Vol.183 (2), p.135-148
Main Authors: Burggren, Warren W, Andrewartha, Sarah J, Tazawa, Hiroshi
Format: Article
Language:English
Subjects:
Acid-Base Equilibrium - physiology
Acid–base balance: disturbances and metabolic compensation
Anaerobiosis
Animals
Carbon Dioxide - physiology
Chick Embryo
Embryonic Development
Environmental gas challenges: hypercapnia, hypercapnic hypoxia, hypoxia and hyperoxia
Erythrocyte Indices - physiology
Erythrocytes - physiology
Hematocrit
Hematocrit: regulation
Hematological respiratory variables
Medical Education
Oxygen - physiology
Pulmonary/Respiratory
Respiration
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Summary:Highlights ► We used chick embryos as a unique model of acid–base and red blood cell regulation. ► Exposure to hypoxia resulted in metabolic acidosis with some difference among ages. ► Hypercapnia, hypercapnic hypoxia or hyperoxia resulted in respiratory acidosis. ► Increased Hct in 1-day hypoxia was due to increased cell volume and cell number. ► Decreased Hct in hypercapnia or hyperoxia was due to decreased blood cell number.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2012.06.011