Autoimmune liver diseases

Autoimmune liver diseases are divided into autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). They play an important role in the differential diagnosis of acute and chronic liver diseases. Diagnostic criteria consist of biochemical parameters (liver...

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Bibliographic Details
Published in:Der Internist (Berlin) 2012-08, Vol.53 (8), p.943-54; quiz 955-6
Main Authors: Pannicke, N, Schramm, C, Lohse, A W
Format: Article
Language:ger
Subjects:
Autoimmune Diseases - complications
Autoimmune Diseases - diagnosis
Autoimmune Diseases - therapy
Diagnosis, Differential
Humans
Liver Diseases - complications
Liver Diseases - diagnosis
Liver Diseases - therapy
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Summary:Autoimmune liver diseases are divided into autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). They play an important role in the differential diagnosis of acute and chronic liver diseases. Diagnostic criteria consist of biochemical parameters (liver function tests, immunoglobulins, autoantibodies), imaging (ultrasound, MRCP, ERCP) and histopathologic characteristics. The treatment of choice in AIH is a combined immunosuppressive therapy of prednisolone and azathioprine. Ursodeoxycholic acid is the treatment of choice for PBC and improves liver biochemistry and prolongs transplant-free survival by slowing histological progression in the majority of patients. To date, there is no effective medical treatment option for patients with PSC.
ISSN:1432-1289
DOI:10.1007/s00108-012-3096-4