Gonadoblastoma in the Ovaries of a Lesser Galago (Galago senegalensis braccatus)

An enlarged right ovary was removed from a 14-year-old lesser galago (Galago senegalensis braccatus). Cytological preparations consisted of a heterogeneous population of neoplastic cells admixed with extracellular hyaline structures and cell-free nuclei. Microscopically, the ovary was replaced with...

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Bibliographic Details
Published in:Journal of comparative pathology 2012-08, Vol.147 (2-3), p.204-208
Main Authors: Irizarry Rovira, A.R., Lynch, S., David, M., Ramos Vara, J.A.
Format: Article
Language:English
Subjects:
Animals
Animals, Zoo
Biomarkers, Tumor - metabolism
cytology
Fatal Outcome
Female
Galago
gonadoblastoma
Gonadoblastoma - metabolism
Gonadoblastoma - pathology
Gonadoblastoma - surgery
Gonadoblastoma - veterinary
Laminin - metabolism
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Ovarian Neoplasms - veterinary
ovary
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Summary:An enlarged right ovary was removed from a 14-year-old lesser galago (Galago senegalensis braccatus). Cytological preparations consisted of a heterogeneous population of neoplastic cells admixed with extracellular hyaline structures and cell-free nuclei. Microscopically, the ovary was replaced with gonadoblastoma and was composed of nests of germinal cells, including large oocyte-like cells, and sex cord-stromal cells arranged in palisading patterns around the germinal cells, the periphery of the nests and around extracellular hyaline material. The animal died 2years after initial diagnosis. Necropsy examination revealed gonadoblastoma in the left ovary. The germinal cells of the tumour in the right and left ovaries were immunoreactive for calretinin, OCT3/4, PGP 9.5, Ki67 and/or faintly for cytokeratins. Sex cord-stromal cells were immunoreactive for calretinin, OCT3/4, GATA-4, E-cadherin and vimentin. Luteinized sex cord-stromal cells were immunoreactive for inhibin-alpha. The extracellular hyaline material was immunoreactive for laminin. This is the first case of gonadoblastoma in a non-human primate.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2012.01.007