Single-trial analysis of auditory evoked potentials improves separation of normal and schizophrenia subjects

Highlights ► Used independent component analysis to estimate the P50 and N100 components on single-trial auditory evoked responses. ► Normal controls responded earlier, their individual responses had significantly higher amplitude and considerably less latency variability compared to schizophrenia p...

Full description

Saved in:
Bibliographic Details
Published in:Clinical neurophysiology 2012-09, Vol.123 (9), p.1810-1820
Main Authors: Iyer, Darshan, Boutros, Nash N, Zouridakis, George
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Adult and adolescent clinical studies
Analysis of Variance
Biological and medical sciences
Brain Mapping
Electrodiagnosis. Electric activity recording
Electroencephalography
Evoked potentials
Evoked Potentials, Auditory - physiology
Female
Humans
Independent component analysis
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
N100
Nervous system
Neurology
P50
Principal Component Analysis
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reaction Time - physiology
Schizophrenia
Schizophrenia - physiopathology
Sensitivity and Specificity
Single trial EP
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Used independent component analysis to estimate the P50 and N100 components on single-trial auditory evoked responses. ► Normal controls responded earlier, their individual responses had significantly higher amplitude and considerably less latency variability compared to schizophrenia patients. ► The latency and amplitude of the P50 and N100 estimated from single trials could classify subjects with 100% accuracy, whereas the same measures computed from average responses provided a maximum of 76% correct classification.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2011.12.021