MWCNT-ruthenium oxide composite paste electrode as non-enzymatic glucose sensor

• Published in: Biosensors & bioelectronics 2012-10, Vol.38 (1), p.278-283
• Main Authors: Tehrani, Ramin M.A., Ab Ghani, Sulaiman
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Biosensing Techniques - instrumentation; Biotechnology; Electrochemical Techniques - instrumentation; Electrodes; Fundamental and applied biological sciences. Psychology; Glucose; Glucose - analysis; Multi-walled carbon nanotube; Nanotubes, Carbon - chemistry; Non-enzymatic; Oxidation-Reduction; Reproducibility of Results; Ruthenium Compounds - chemistry; Ruthenium oxide; Sensitivity and Specificity
• ISSN: 0956-5663; 1873-4235
• DOI: 10.1016/j.bios.2012.05.044

A non-enzymatic glucose sensor of multi-walled carbon nanotube–ruthenium oxide/composite paste electrode (MWCNT–RuO2/CPE) was developed. The electrode was characterized by using XRD, SEM, TEM and EIS. Meanwhile, cyclic voltammetry and amperometry were used to check on the performances of the MWCNT–RuO2/CPE towards glucose. The proposed electrode has displayed a synergistic effect of RuO2 and MWCNT on the electrocatalytic oxidation of glucose in 3M NaOH. This was possible via the formation of transitions of two redox pairs, viz. Ru(VI)/Ru(IV) and Ru(VII)/Ru(VI). A linear range of 0.5–50mM glucose and a limit of detection of 33μM glucose (S/N=3) were observed. There was no significant interference observable from the traditional interferences, viz. ascorbic acid and uric acid. Indeed, results so obtained have indicated that the developed MWCNT–RuO2/CPE would pave the way for a better future to glucose sensor development as its fabrication was without the use of any enzyme. ► A simple non-enzymatic glucose sensor using MWCNT and RuO2 has been developed. ► The synergistic of RuO2 and MWCNT in the catalysis of glucose is observed. ► The transitions of redox pairs Ru(VI)/Ru(IV) and Ru(VII)/Ru(VI) are anticipated. ► The sensor exhibits good sensitivity, reproducibility, stability and reliability. ► In high pH medium it is not interfered by ascorbic and uric acids.