Gonadotropin signalling in epithelial ovarian cancer

Ovarian cancer is the most lethal of all gynecologic malignancies, although its aetiology remains poorly understood. A role for the gonadotropins, follicle-stimulating hormone (FSH) and luteinising hormone (LH), has been implicated in a variety of different aspects of ovarian cancer tumorigenesis, i...

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Bibliographic Details
Published in:Cancer letters 2012-11, Vol.324 (2), p.152-159
Main Authors: Mertens-Walker, Inga, Baxter, Robert C, Marsh, Deborah J
Format: Article
Language:English
Subjects:
animal ovaries
Animals
Antineoplastic Agents, Hormonal - metabolism
Antineoplastic Agents, Hormonal - therapeutic use
carcinogenesis
Carcinoma, Ovarian Epithelial
cell proliferation
etiology
Female
Follicle Stimulating Hormone - metabolism
follicle-stimulating hormone
FSH
gene expression
Gonadotropins
Gonadotropins - genetics
Gonadotropins - metabolism
Hematology, Oncology and Palliative Medicine
Humans
Infertility
Ligands
luteinizing hormone
Luteinizing Hormone - metabolism
Medical research
Menopause
Mortality
Neoplasms, Glandular and Epithelial - drug therapy
Neoplasms, Glandular and Epithelial - genetics
Neoplasms, Glandular and Epithelial - metabolism
Neoplasms, Glandular and Epithelial - pathology
Ovarian cancer
ovarian neoplasms
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - genetics
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Receptors, Gonadotropin - metabolism
Signal Transduction - drug effects
Signalling pathways
Studies
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Summary:Ovarian cancer is the most lethal of all gynecologic malignancies, although its aetiology remains poorly understood. A role for the gonadotropins, follicle-stimulating hormone (FSH) and luteinising hormone (LH), has been implicated in a variety of different aspects of ovarian cancer tumorigenesis, including cellular proliferation, migration and invasion. This review focuses on the latest advances in knowledge concerning signalling pathways and functional consequences of gonadotropin action, including changes in protein-, miRNA- and gene expression, in epithelial ovarian cancer cells.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2012.05.017