Severe hyperlipidaemia complicating diabetic ketoacidosis

Original reports did not establish a relationship to ketoacidosis, but the phenomenon was attributed to chronic insulin insufficiency. 1 The exact mechanism is unclear but transient insulin deficiency may cause a decrease in the activity of lipoprotein lipase, accounting for the much more common mod...

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Bibliographic Details
Published in:Archives of disease in childhood 2012-08, Vol.97 (8), p.735-735
Main Authors: Williamson, Scott, Alexander, Vicky, Greene, Stephen Alan
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Gas Analysis
Child
Diabetes
Diabetic Ketoacidosis - blood
Diabetic Ketoacidosis - complications
Diabetic Ketoacidosis - therapy
Disorders of blood lipids. Hyperlipoproteinemia
Electrolytes - blood
Female
Females
Fluid Therapy - methods
General aspects
Humans
Hypertriglyceridemia - blood
Hypertriglyceridemia - etiology
Hypertriglyceridemia - therapy
Insulin
Medical sciences
Metabolic diseases
Miscellaneous
Prevention and actions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Treatment Outcome
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Summary:Original reports did not establish a relationship to ketoacidosis, but the phenomenon was attributed to chronic insulin insufficiency. 1 The exact mechanism is unclear but transient insulin deficiency may cause a decrease in the activity of lipoprotein lipase, accounting for the much more common moderate hyperlipidaemia. 2 Abnormalities in the gene for this enzyme have also been implicated in another case of severe hyperlipidaemia and DKA in a child. 3 Electrolyte analysis is carried out on the water fraction of plasma.
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2012-301810