Recent Advances in Catalytic Enantioselective Fluorination Reactions

Since the incorporation of fluorine into biologically active compounds often enhances the properties of the parent compounds, there is a considerable demand for efficient enantioselective fluorination reactions. Over the past decade, a range of metal‐catalyzed and organocatalyzed fluorination reacti...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2010-11, Vol.352 (16), p.2708-2732
Main Authors: Lectard, Sylvain, Hamashima, Yoshitaka, Sodeoka, Mikiko
Format: Article
Language:English
Subjects:
asymmetric catalysis
Catalysis
Catalysts
Demand
electrophilic fluorination
Fluorination
Fluorine
fluorine chemistry
Marketing
nucleophilic fluorination
organocatalysis
organometallic catalysis
Parents
Synthesis
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Summary:Since the incorporation of fluorine into biologically active compounds often enhances the properties of the parent compounds, there is a considerable demand for efficient enantioselective fluorination reactions. Over the past decade, a range of metal‐catalyzed and organocatalyzed fluorination reactions has been developed. Nowadays, fluorine can be catalytically introduced into many compounds in good yield and with high enantioselectivity, and the scope of these reactions is broad. Herein, we review recent progress in the field of catalytic enantioselective fluorination reactions, including their scope and mechanism.
ISSN:1615-4150
1615-4169
1615-4169
DOI:10.1002/adsc.201000624