Bifunctional Silica-Coated Superparamagnetic FePt Nanoparticles for Fluorescence/MR Dual Imaging

Recently, superparamagnetic chemically disordered face-centered cubic (fcc) FePt nanoparticles have been demonstrated as superior negative contrast agents for magnetic resonance imaging (MRI). However, their low intracellular labeling efficiency has limited the potential usage and the nanotoxicity o...

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Bibliographic Details
Published in:Journal of nanomaterials 2012-01, Vol.2012 (2012), p.1-7
Main Authors: Liao, Ming-Yuan, Tsai, Jai-Lin, Hsu, Chia-Yen, Tsai, Tsiao-Yu, Lai, Syu-Ming, Lai, Ping-Shan
Format: Article
Language:English
Subjects:
Aqueous solutions
Cell culture
Contrast agents
Cytotoxicity
Ethanol
Ferrous alloys
Glass substrates
Grain size
Intermetallics
Iron compounds
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Platinum compounds
Surfactants
Temperature
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Summary:Recently, superparamagnetic chemically disordered face-centered cubic (fcc) FePt nanoparticles have been demonstrated as superior negative contrast agents for magnetic resonance imaging (MRI). However, their low intracellular labeling efficiency has limited the potential usage and the nanotoxicity of the particles requires attention. We have developed fluorescein isothiocyanate-incorporated silica-coated FePt (FePt@SiO2-FITC) nanoparticles that exhibited not only a significant T1 and T2 MR contrast abilities but also a fluorescent property without significant cytotoxicities. These results suggest that silica-coated superparamagnetic FePt nanoparticles are potential nanodevices for the combination of fluorescence and MRI contrast used for cancer diagnosis.
ISSN:1687-4110
1687-4129
DOI:10.1155/2012/631584