Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation

• Published in: Clinical transplantation 2012-05, Vol.26 (3), p.476-483
• Main Authors: Cho, Hyeon Jin, Shin, Dong-Yeop, Kim, Jin Hee, Bae, Ji-Yeon, Lee, Kyung-Hun, See, Cha Ja, Kim, Naeyu, Park, Eun Kyung, Ra, Eun Kyung, Lee, Jong-Eun, Hong, Yun-Chul, Kim, Hyun Kyung, Park, Sung Sup, Yoon, Sung-Soo, Lee, Dong Soon, Han, Kyou-Sup, Park, Myoung Hee, Park, Seonyang, Kim, Byoung Kook, Kim, Inho
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone marrow, stem cells transplantation. Graft versus host reaction; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genotype; Graft vs Host Disease - etiology; Graft vs Host Disease - mortality; Hematopoietic Stem Cell Transplantation - adverse effects; Histocompatibility; HLA Antigens - immunology; Humans; Leukemia, Myeloid - complications; Leukemia, Myeloid - mortality; Leukemia, Myeloid - therapy; Male; Medical sciences; Middle Aged; polymorphism; Polymorphism, Genetic - genetics; Prognosis; Receptors, Calcitriol - genetics; Siblings; stem cell transplantation; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Rate; Tissue, organ and graft immunology; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; vitamin D receptor; Young Adult
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1111/j.1399-0012.2011.01523.x

Cho HJ, Shin DY, Kim JH, Bae JY, Lee KH, See CJ, Kim N, Park EK, Ra EK, Lee JE, Hong YC, Kim HK, Park SS, Yoon SS, Lee DS, Han KS, Park MH, Park S, Kim BK, Kim I. Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA‐matched sibling hematopoietic stem cell transplantation. 
Clin Transplant 2011 DOI: 10.1111/j.1399‐0012.2011.01523.x. 
© 2011 John Wiley & Sons A/S. :  We hypothesized that polymorphisms of the vitamin D receptor (VDR) gene might affect clinical outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Three VDR gene polymorphisms (BsmI G>A, ApaI G>T, and TaqI T>C) were genotyped in 147 patients who underwent HLA‐matched sibling allogeneic HSCT. Frequencies of infection, graft‐vs.‐host disease (GVHD), overall survival (OS), and disease‐free survival (DFS) were compared according to genotypes and haplotypes. Infection and acute GVHD had trends to be less frequent in patients with ApaI TT genotype than non‐TT genotypes (p = 0.061 and p = 0.059, respectively). For TaqI genotypes, there were no statistical differences in frequency of infection and acute GVHD (p = 0.84 and p = 0.30, respectively), but TC genotype was associated with longer OS and DFS than TT genotype (p = 0.022 and p = 0.038, respectively). In the ApaI‐TaqI haplotype analysis, patients with TC haplotype had significantly longer OS and DFS than those without TC haplotype (p = 0.022 and p = 0.038, respectively). In multivariable analysis, TaqI genotype and ApaI‐TaqI haplotype of recipients were independent prognostic factors for both OS and DFS. This study suggests that the genotype and haplotype of VDR in recipient might be associated with clinical outcome of sibling HLA‐matched HSCT.