Cationic Peptidopolysaccharides Show Excellent Broad-Spectrum Antimicrobial Activities and High Selectivity

Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan‐mimetic structure, show outstanding broad‐spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell‐wall constituents p...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2012-08, Vol.24 (30), p.4130-4137
Main Authors: Li, Peng, Zhou, Chuncai, Rayatpisheh, Shahrzad, Ye, Kai, Poon, Yin Fun, Hammond, Paula T., Duan, Hongwei, Chan-Park, Mary B.
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
antimicrobial polymers
Bacteria - cytology
Bacteria - drug effects
biocompatible
biomedical
Biomimetic Materials - chemistry
Biomimetic Materials - pharmacology
Cell Wall - chemistry
chitosan
Chitosan - chemistry
Fungi - drug effects
Microbial Sensitivity Tests
Peptidoglycan - chemistry
peptidopolysaccharide
Polylysine - chemistry
Species Specificity
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Summary:Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan‐mimetic structure, show outstanding broad‐spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell‐wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201104186