Co-regulation of survival of motor neuron and Bcl-xL expression: Implications for neuroprotection in spinal muscular atrophy

Highlights ► Expression of SMN and Bcl-xL is co-regulated. ► Bcl-xL levels are increased in PrP-SMN transgenic mouse brains. ► SMN and Bcl-xL expression reduce Sam68 levels. ► Co-expression of SMN and Bcl-xL additively protects against apoptosis. ► Exogenous SMN expression increases endogenous FL-SM...

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Published in:Neuroscience 2012-09, Vol.220, p.228-236
Main Authors: Anderton, R.S, Price, L.L, Turner, B.J, Meloni, B.P, Mitrpant, C, Mastaglia, F.L, Goh, C, Wilton, S.D, Boulos, S
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - metabolism
additive
Animals
bcl-X Protein - metabolism
Bcl-xL
Biological and medical sciences
Blotting, Western
Cell Line
co-expression
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Humans
Mice
Mice, Transgenic
Motor Neurons - metabolism
Muscular Atrophy, Spinal - metabolism
Neurology
PrP-SMN
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA-Binding Proteins - metabolism
Sam68
SMN
Survival of Motor Neuron 1 Protein - metabolism
Transduction, Genetic
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Expression of SMN and Bcl-xL is co-regulated. ► Bcl-xL levels are increased in PrP-SMN transgenic mouse brains. ► SMN and Bcl-xL expression reduce Sam68 levels. ► Co-expression of SMN and Bcl-xL additively protects against apoptosis. ► Exogenous SMN expression increases endogenous FL-SMN transcript levels.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.06.042