Mechanisms mediating effects of nitric oxide on perifornical lateral hypothalamic neurons

Highlights ► The perifornical-lateral hypothalamic area (PF-LHA) is a wake-promoting region. ► Nitric oxide (NO), a sleep-promoting factor, inhibits majority of PF-LHA neurons. ► Blockade of sGC-cGMP signaling attenuated NO-evoked suppression of PF-LHA neurons. ► Blockade of GABAA as well as adenosi...

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Bibliographic Details
Published in:Neuroscience 2012-09, Vol.220, p.179-190
Main Authors: Kostin, A, McGinty, D, Szymusiak, R, Alam, M.N
Format: Article
Language:English
Subjects:
Action Potentials - physiology
adenosine
Animals
Biological and medical sciences
Electroencephalography
Fundamental and applied biological sciences. Psychology
GABA
Hypothalamic Area, Lateral - metabolism
Male
Neurology
Neurons - metabolism
Neurotransmitter Agents - metabolism
nitric oxide
Nitric Oxide - metabolism
perifornical-lateral hypothalamus
posterior-lateral hypothalamus
Rats
Rats, Sprague-Dawley
Signal Transduction - physiology
sleep
Vertebrates: nervous system and sense organs
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Summary:Highlights ► The perifornical-lateral hypothalamic area (PF-LHA) is a wake-promoting region. ► Nitric oxide (NO), a sleep-promoting factor, inhibits majority of PF-LHA neurons. ► Blockade of sGC-cGMP signaling attenuated NO-evoked suppression of PF-LHA neurons. ► Blockade of GABAA as well as adenosine A1 receptors also attenuated NO-evoked actions. ► Adenosinergic, GABAergic and sGC-cGMP mechanisms contribute to the actions of NO on PF-LHA neurons.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.06.014