MDR1 single nucleotide polymorphism C3435T in Turkish patients with non-small-cell lung cancer

• Published in: Gene 2012-09, Vol.506 (2), p.404-407
• Main Authors: Dogu, Gamze Gokoz, Kargi, Aysegul, Turgut, Sebahat, Ayada, Ceylan, Taskoylu, Burcu Yapar, Demiray, Gokcen, Yaren, Arzu, Ozlu, Can, Temel, Sahin, Ergin, Ahmet
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; albumins; ATP Binding Cassette Transporter, Sub-Family B; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics; C3435T polymorphism; Carcinoma, Non-Small-Cell Lung - ethnology; Carcinoma, Non-Small-Cell Lung - genetics; Disease-Free Survival; Female; gene frequency; genes; Genotype; Humans; lung neoplasms; Lung Neoplasms - ethnology; Lung Neoplasms - genetics; Male; MDR1; Middle Aged; Models, Genetic; Non-small cell lung cancer (NSCLC); P-glycoprotein; patients; Platinum; Polymorphism, Single Nucleotide; Regression Analysis; single nucleotide polymorphism; Turkey
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2012.06.057

We assessed whether single nucleotide polymorphisms (SNPs) in MDR1 gene C3435T predicted the outcome of platinum-based chemotherapies and survival in our non small cell lung cancer (NSCLC) patients. A total of 79 non-small cell lung cancer patients were enrolled to study. We determined the MDR1 C3435T single nucleotide gene polymorphisms. Median age was 60years: 91.7% male, 8.9% female. We found that CC, CT, TT genotype and T, C allele frequencies in lung cancer patients as 24.1%, 62%, 13.9% and 44.3%, 55.7%, respectively. Patients with CT genotype had a higher response rate (11.4%) than the other genotypes. However, this difference is not statistically significant (p=0.743). Cox regression analysis for overall survival showed that ECOG PS status 0 (HR PS 1 vs. 0, 5.68 p=0.002; HR of PS 2 vs. 0 is 21.579, p=0.001; HR of PS 3 vs. 0 is 35.35, p=0.001), stage ≤II (HR of stage III vs. I+II is 17.77; p=0.016, HR of stage IV vs. I+II is 26.97, p=0.006), and albumin level ≥3g/dl (HR of albumin