Binding ability properties of β-cyclodextrin dimers linked through their secondary faces towards cancer chemotherapeutic agent methotrexate

The binding ability properties of two β-cyclodextrin dimers linked through their secondary faces by short, rigid spacer arms towards the cancer chemotherapeutic agent methotrexate were studied by ITC and NMR (1D and ROESY) experiments. Both dimers are able to bind two molecules of methotrexate with...

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Bibliographic Details
Published in:Journal of drug delivery science and technology 2012, Vol.22 (3), p.270-272
Main Authors: Aykaç, A., Martos-Maldonado, M.C., Casas-Solvas, J.M., García-Fuentes, L., Vargas-Berenguel, A.
Format: Article
Language:English
Subjects:
beta -Cyclodextrin
Binding constants
Calorimetry
Cancer
Chemotherapy
Complexation ability
Drug delivery
Methotrexate
N.M.R
NMR
Solubility
Spacer
β-Cyclodextrin dimers
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Summary:The binding ability properties of two β-cyclodextrin dimers linked through their secondary faces by short, rigid spacer arms towards the cancer chemotherapeutic agent methotrexate were studied by ITC and NMR (1D and ROESY) experiments. Both dimers are able to bind two molecules of methotrexate with a binding constant between 2.4 and 3.5 times higher than that for native β-cyclodextrin, the dimer having the shortest linker forming the most stable complex.
ISSN:1773-2247
DOI:10.1016/S1773-2247(12)50039-0