Biopersistence of Refractory Ceramic Fiber in Human Lung Tissue and a 20-Year Follow-Up of Radiographic Pleural Changes in Workers

OBJECTIVE:The biopersistence of refractory ceramic fiber (RCF) in human lung tissue is unknown and may contribute to an association between cumulative fiber exposure and radiographic changes. METHODS:Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest...

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Published in:Journal of occupational and environmental medicine 2012-07, Vol.54 (7), p.781-788
Main Authors: Lockey, James E, Roggli, Victor L, Hilbert, Timothy J, Rice, Carol H, Levin, Linda S, Borton, Eric K, Biddinger, Paul W, LeMasters, Grace K
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Ceramics
Chemical and industrial products toxicology. Toxic occupational diseases
Female
Humans
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Longitudinal Studies
Lung - diagnostic imaging
Male
Medical sciences
Middle Aged
Mineral Fibers
Occupational Exposure
Pleura - diagnostic imaging
Radiography
Toxicology
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container_issue 7
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container_title Journal of occupational and environmental medicine
container_volume 54
creator Lockey, James E
Roggli, Victor L
Hilbert, Timothy J
Rice, Carol H
Levin, Linda S
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Biddinger, Paul W
LeMasters, Grace K
description OBJECTIVE:The biopersistence of refractory ceramic fiber (RCF) in human lung tissue is unknown and may contribute to an association between cumulative fiber exposure and radiographic changes. METHODS:Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest radiograph study of 1323 workers was conducted. RESULTS:Within lung tissue, RCF comprised 14% to 100% of fibers 5 μm or more in length and was identified up to 20 years after RCF employment. Among workers with no reported asbestos exposure, cumulative exposure of more than 63 to 110 and more than 110 fiber-months/cm was associated with radiographic pleural changes of 8.5% (odds ratio, 7.2; 95% confidence interval, 1.4 to 36.8) and 11.6% (odds ratio, 10.3; 95% confidence interval, 2.1 to 49.9), respectively. CONCLUSIONS:Refractory ceramic fiber can persist in human lung tissue for up to 20 years and may contribute to the significant association between cumulative fiber exposure and radiographic pleural changes.
doi_str_mv 10.1097/JOM.0b013e31825296fd
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METHODS:Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest radiograph study of 1323 workers was conducted. RESULTS:Within lung tissue, RCF comprised 14% to 100% of fibers 5 μm or more in length and was identified up to 20 years after RCF employment. Among workers with no reported asbestos exposure, cumulative exposure of more than 63 to 110 and more than 110 fiber-months/cm was associated with radiographic pleural changes of 8.5% (odds ratio, 7.2; 95% confidence interval, 1.4 to 36.8) and 11.6% (odds ratio, 10.3; 95% confidence interval, 2.1 to 49.9), respectively. 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METHODS:Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest radiograph study of 1323 workers was conducted. RESULTS:Within lung tissue, RCF comprised 14% to 100% of fibers 5 μm or more in length and was identified up to 20 years after RCF employment. Among workers with no reported asbestos exposure, cumulative exposure of more than 63 to 110 and more than 110 fiber-months/cm was associated with radiographic pleural changes of 8.5% (odds ratio, 7.2; 95% confidence interval, 1.4 to 36.8) and 11.6% (odds ratio, 10.3; 95% confidence interval, 2.1 to 49.9), respectively. 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METHODS:Lung tissue fiber was analyzed for a case series of 10 RCF workers and a 20-year longitudinal chest radiograph study of 1323 workers was conducted. RESULTS:Within lung tissue, RCF comprised 14% to 100% of fibers 5 μm or more in length and was identified up to 20 years after RCF employment. Among workers with no reported asbestos exposure, cumulative exposure of more than 63 to 110 and more than 110 fiber-months/cm was associated with radiographic pleural changes of 8.5% (odds ratio, 7.2; 95% confidence interval, 1.4 to 36.8) and 11.6% (odds ratio, 10.3; 95% confidence interval, 2.1 to 49.9), respectively. 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ispartof Journal of occupational and environmental medicine, 2012-07, Vol.54 (7), p.781-788
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source JSTOR Archival Journals and Primary Sources Collection
subjects Adult
Aged
Aged, 80 and over
Biological and medical sciences
Ceramics
Chemical and industrial products toxicology. Toxic occupational diseases
Female
Humans
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Longitudinal Studies
Lung - diagnostic imaging
Male
Medical sciences
Middle Aged
Mineral Fibers
Occupational Exposure
Pleura - diagnostic imaging
Radiography
Toxicology
title Biopersistence of Refractory Ceramic Fiber in Human Lung Tissue and a 20-Year Follow-Up of Radiographic Pleural Changes in Workers
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