Bioavailability, Distribution, and Antioxidative Effects of Selected Triterpenes in Mice

This study analyzed the content of eight triterpenes (oleanolic acid, ursolic acid, arjunolic acid, asiatic acid, boswellic acid, corosolic acid, madecassic acid, and maslinic acid) in ten vegetables and eight fruits. These compounds at 0.5% were supplied to mice for 4 or 8 weeks. The bioavailabilit...

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Published in:Journal of agricultural and food chemistry 2012-08, Vol.60 (31), p.7697-7701
Main Authors: Yin, Mei-Chin, Lin, Ming-Cheng, Mong, Mei-Chin, Lin, Chia-Yu
Format: Article
Language:English
Subjects:
Animals
antioxidant activity
Antioxidants - analysis
Antioxidants - pharmacokinetics
basil
bioavailability
Biological and medical sciences
Biological Availability
bladder
brain
colon
Feeding. Feeding behavior
Food industries
Fruit - chemistry
Fruit and vegetable industries
fruits
Fundamental and applied biological sciences. Psychology
heart
Humans
kidneys
liver
Male
Mice
Mice, Inbred C57BL
mustard
oleanolic acid
Plant Extracts - analysis
Plant Extracts - pharmacokinetics
tissue distribution
Triterpenes - analysis
Triterpenes - pharmacokinetics
ursolic acid
vegetables
Vegetables - chemistry
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:This study analyzed the content of eight triterpenes (oleanolic acid, ursolic acid, arjunolic acid, asiatic acid, boswellic acid, corosolic acid, madecassic acid, and maslinic acid) in ten vegetables and eight fruits. These compounds at 0.5% were supplied to mice for 4 or 8 weeks. The bioavailability, tissue distribution, and antioxidative protection of these triterpenes were examined. Results showed that triterpenes were detected in eight vegetables and six fruits. Basil and brown mustard contained seven test triterpenes, in the range of 14–102 mg/100 g dry weight. The level of each triterpene in plasma, brain, heart, liver, kidney, colon, and bladder increased as the feeding period was increased from 4 weeks to 8 weeks (P < 0.05). Renal homogenates from mice with triterpene intake had greater antioxidative effects against glucose-induced glutathione loss and malondialdehyde and oxidized glutathione production when compared with those from control groups (P < 0.05). These data support that these triterpenes were absorbed and deposited in their intact forms, which in turn exerted in vivo antioxidative protection.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf302529x