Enhancement of the acute phase response to a lipopolysaccharide challenge in steers supplemented with chromium

The study examined the effect of chromium supplementation on the response of steers to an LPS challenge. Steers received a premix that added 0 (control; n = 10) or 0.2 mg/kg of chromium (n = 10) to the total diet on a dry matter basis for 56 d. Steers were fitted with jugular catheters and rectal te...

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Bibliographic Details
Published in:Innate immunity (London, England) England), 2012-08, Vol.18 (4), p.592-601
Main Authors: Burdick, Nicole C, Bernhard, Bryan C, Carroll, Jeffery A, Rathmann, Ryan J, Johnson, Bradley J
Format: Article
Language:English
Subjects:
Acute-Phase Reaction - immunology
Acute-Phase Reaction - veterinary
Animals
Cattle
Cells, Cultured
Cytokines - genetics
Cytokines - metabolism
Diet
Dietary Supplements
Disease Progression
Endotoxemia - immunology
Endotoxemia - veterinary
Gene Expression Regulation
Immunomodulation
Lipopolysaccharides - immunology
Male
Propionates - administration & dosage
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Summary:The study examined the effect of chromium supplementation on the response of steers to an LPS challenge. Steers received a premix that added 0 (control; n = 10) or 0.2 mg/kg of chromium (n = 10) to the total diet on a dry matter basis for 56 d. Steers were fitted with jugular catheters and rectal temperature (RT) recording devices on d 52. Blood samples were collected and sickness behavior scores assigned to each steer relative to an LPS challenge (0.5 µg/kg) on d 55. Pre-LPS RT were greater in chromium-supplemented than in control steers. Post-LPS RT increased in both treatments, with control steers producing a greater change in RT than chromium-supplemented steers. Sickness behavior scores were greater in control than in chromium-supplemented steers post-LPS (P = 0.03). Cortisol concentrations did not differ between treatments pre-LPS. Post-LPS cortisol concentrations increased but did not differ due to treatment. Concentrations of IL-4 increased post-LPS but were not affected by treatment pre- or post-LPS. Treatment did not affect pre-LPS TNF-α or IFN-γ. Post-LPS TNF-α and IFN-γ increased in both treatments, with chromium-supplemented steers producing greater TNF-α (P = 0.005) and IFN-γ (P = 0.004) than control steers. Pre-LPS IL-6 was greater (P = 0.027) in chromium-supplemented steers than in control steers. Post-LPS IL-6 increased in both treatments and was greater (P 
ISSN:1753-4259
1753-4267
DOI:10.1177/1753425911428964