Normobaric hyperoxia affects osteogenesis in rats

We studied the influence of normobaric hyperoxia on bone metabolism in 3- and 12-month-old male Wistar rats. Maintaining young rats (3 months) during the 14-hour daily sessions under normobaric hyperoxia (90% O2) was accompanied by a significant decrease in the concentration of C-terminal propeptide...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2012, Vol.58 (2), p.51-58
Main Authors: Litovka, I H, Berezovs'kyĭ, V Ia, Zamors'ka, T M
Format: Article
Language:eng ; ukr
Subjects:
Acid Phosphatase - blood
Alkaline Phosphatase - blood
Amino Acids - blood
Animals
Bone and Bones - drug effects
Collagen - blood
Glycosaminoglycans - blood
Hyperoxia - blood
Male
Osteoblasts - drug effects
Osteoblasts - pathology
Osteogenesis - drug effects
Oxygen - adverse effects
Oxygen Consumption
Protein Precursors - blood
Rats
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Summary:We studied the influence of normobaric hyperoxia on bone metabolism in 3- and 12-month-old male Wistar rats. Maintaining young rats (3 months) during the 14-hour daily sessions under normobaric hyperoxia (90% O2) was accompanied by a significant decrease in the concentration of C-terminal propeptides of collagen type I (by 36%), the acid phosphatase activity (by 32%), an increased activity of alkaline phosphatase (by 64%), an increased concentration of pyridinoline (by 37%) and 3-CrossLaps (by 8%), glycosaminoglycans (by 72%) in the blood serum. We believe that normobaric hyperoxia (90%) is accompanied by the disturbance of collagen synthesis. In adult rats under the same conditions for 14 sessions, the concentration ofglycosaminoglicans significantly increased by 60% relative to the control values. After 28 sessions of breathing the normobaric gas mixture containing 90% O 2 this parameter increased by 195%. Breathing normobaric gas mixture containing both 40% and 90% of O2 for 14 and 28 days decreased the acid phosphatase activity and the tartrat-resistant acid phosphatase activity by 18-25%. We believe that in adult animals 90% hyperoxia does not affect the activity of osteoblasts, but breaks the link between glycosaminoglicans and collagen fibrils, decreases the activity oflysosomal enzymes which are produced by osteoclasts and which can inhibit osteogenesis.
ISSN:2522-9028
2522-9036
DOI:10.15407/fz58.02.051