20-20: Alcohol and Age-related Macular Degeneration The Melbourne Collaborative Cohort Study

Little evidence exists regarding associations between age-related macular degeneration (AMD) and moderate alcohol consumption, patterns of consumption, or different types of alcoholic beverage. The authors examined associations between AMD prevalence and alcohol intake using 20,963 participants from...

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Bibliographic Details
Published in:American journal of epidemiology 2012-08, Vol.176 (4), p.289-298
Main Authors: ADAMS, Madeleine K. M, CHONG, Elaine W, ROBMAN, Liubov D, SIMPSON, Julie A, WILLIAMSON, Elizabeth, ZAW AUNG, Khin, MAKEYEVA, Galina A, GILES, Graham G, ENGLISH, Dallas R, HOPPER, John, GUYMER, Robyn H, BAIRD, Paul N
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Alcohol use
Alcoholic beverages
Alcoholism
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Cohort Studies
Diet
Epidemiology
Female
Follow-Up Studies
General aspects
Health Surveys
Humans
Interviews as Topic
Logistic Models
Macular degeneration
Macular Degeneration - diagnosis
Macular Degeneration - epidemiology
Macular Degeneration - etiology
Male
Medical sciences
Middle Aged
Miscellaneous
Multivariate Analysis
Odds Ratio
Prevalence
Prospective Studies
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Smoking
Toxicology
Victoria - epidemiology
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Summary:Little evidence exists regarding associations between age-related macular degeneration (AMD) and moderate alcohol consumption, patterns of consumption, or different types of alcoholic beverage. The authors examined associations between AMD prevalence and alcohol intake using 20,963 participants from the Melbourne Collaborative Cohort Study aged 40-69 years at baseline (1990-1994). Participants' alcohol consumption was determined from a structured interview at baseline. At follow-up from 2003 to 2007, digital macula photographs of both eyes were taken and evaluated for early and late AMD signs. Drinking more than 20 g of alcohol per day was associated with an approximate 20% increase in the odds of early AMD (odds ratio = 1.21, 95% confidence interval: 1.06, 1.38; P = 0.004) when compared with those who reported no alcohol intake at baseline, having adjusted for sex, age, smoking, country of birth, education, physical activity, and energy from food. This positive association was apparent for wine, beer, and spirits. The estimates were similar for both sexes. The odds ratio for those drinking more than 20 g of alcohol per day for late AMD was 1.44 (95% confidence interval: 0.85, 2.45; P = 0.17). These results show a modest association between alcohol consumption and increased AMD risk.
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kws004