Coexistence of sickle cell disease and severe congenital neutropenia: first impressions can be deceiving

We report an Omani family in whom the propositus had a rare coexistence of sickle cell disease and severe congenital neutropenia associated with a mutation in ELANE. In contrast to his siblings with sickle cell disease, the severity of HbSS‐associated complications such as painful crises and acute c...

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Bibliographic Details
Published in:European journal of haematology 2012-09, Vol.89 (3), p.245-249
Main Authors: Wali, Yasser, Beshlawi, Ismail, Fawaz, Naglaa, Alkhayat, Aisha, Zalabany, Mahmoud, Elshinawy, Mohamed, Al-Kindi, Salam, Al-Rawas, Abdul Hakim A., Klein, Christoph
Format: Article
Language:English
Subjects:
Anemia, Sickle Cell - complications
Humans
Male
Neutropenia - complications
Neutropenia - congenital
severe congenital neutropenia
sickle
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Summary:We report an Omani family in whom the propositus had a rare coexistence of sickle cell disease and severe congenital neutropenia associated with a mutation in ELANE. In contrast to his siblings with sickle cell disease, the severity of HbSS‐associated complications such as painful crises and acute chest syndrome was significantly reduced. His course of the disease had markedly worsened after initiating G‐CSF therapy. These clinical observations suggest that neutropenia may ameliorate inflammatory responses and thus display a modulating factor with respect to the clinical course of sickle cell disease.
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.2012.01827.x