The p38 and Hog1 SAPKs control cell cycle progression in response to environmental stresses

In response to environmental stresses, cells need to activate an adaptive program to maximize cell progression and survival. Stress-activated protein kinases (SAPK) are key signal transduction kinases required to respond to stress. Prototypical members of SAPKs are the yeast Hog1 and mammalian p38....

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Bibliographic Details
Published in:FEBS letters 2012-08, Vol.586 (18), p.2925-2931
Main Authors: Duch, Alba, de Nadal, Eulàlia, Posas, Francesc
Format: Article
Language:English
Subjects:
Cell Cycle
Cell cycle regulation
Mitogen-Activated Protein Kinases - metabolism
p38 Mitogen-Activated Protein Kinases - metabolism
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae Proteins - metabolism
SAPK
Signal Transduction
Stress-response
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Summary:In response to environmental stresses, cells need to activate an adaptive program to maximize cell progression and survival. Stress-activated protein kinases (SAPK) are key signal transduction kinases required to respond to stress. Prototypical members of SAPKs are the yeast Hog1 and mammalian p38. Upon stress, those enzymes play a critical role in mounting the adaptive responses to stress such as the regulation of metabolism and the control of gene expression. In addition, a major function of SAPKs in response to stress is to modulate cell cycle progression. In this review, we focus on the role of Hog1 and p38 in the control of cell cycle progression in response to environmental stresses.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2012.07.034