Effects of ozone therapy on haemostatic and oxidative stress index in coronary artery disease

Coronary artery disease (CAD) is the most common cause of sudden death, and death of people over 20 years of age. Because ozone therapy can activate the antioxidant system and improve blood circulation and oxygen delivery to tissue, the aim of this study was to investigate the therapeutic efficacy o...

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Bibliographic Details
Published in:European journal of pharmacology 2012-09, Vol.691 (1-3), p.156-162
Main Authors: Martínez-Sánchez, Gregorio, Delgado-Roche, Livan, Díaz-Batista, Arquímides, Pérez-Davison, Gema, Re, Lamberto
Format: Article
Language:English
Subjects:
adverse effects
Aged
Aged, 80 and over
antioxidants
Antioxidants - metabolism
Aspirin
Aspirin - therapeutic use
biomarkers
Biomarkers - metabolism
blood circulation
catalase
clinical trials
coronary artery disease
Coronary Artery Disease - drug therapy
Coronary Artery Disease - metabolism
Coronary Artery Disease - physiopathology
Coronary artery diseases
death
Fatty Alcohols - therapeutic use
Female
gender
hemorrhage
Hemostasis - drug effects
Humans
hydrogen peroxide
lipid peroxidation
Male
Middle Aged
Oxidative stress
Oxidative Stress - drug effects
oxygen
ozonation
Ozone
Ozone - pharmacology
Ozone - therapeutic use
patients
people
pharmacology
Policosanol
prothrombin
Reactive Oxygen Species - metabolism
superoxide dismutase
therapeutics
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Summary:Coronary artery disease (CAD) is the most common cause of sudden death, and death of people over 20 years of age. Because ozone therapy can activate the antioxidant system and improve blood circulation and oxygen delivery to tissue, the aim of this study was to investigate the therapeutic efficacy of ozone in patients with CAD, treated with antithrombotic therapy, Aspirin® and policosanol. A randomized controlled clinical trial was performed with 53 patients divided into two groups: one (n=27) treated with antithrombotic therapy and other (n=26) treated with antithrombotic therapy plus rectal insufflation of O3. A parallel group (n=50) age and gender matched was used as reference for the experimental variables. The efficacy of the treatments was evaluated by comparing hemostatic indexes and biochemical markers of oxidative stress in both groups after 20 day of treatment. Ozone treatment significantly (P
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2012.07.010