Quercetin as a prophylactic measure against high altitude cerebral edema

The present study was undertaken to elucidate the intervention of quercetin against high altitude cerebral edema (HACE) using male Sprague Dawley rats as an animal model. This study was also programmed to compare and correlate the effect of both quercetin (flavonoid) and dexamethasone (steroid) agai...

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Bibliographic Details
Published in:Free radical biology & medicine 2012-08, Vol.53 (4), p.659-668
Main Authors: Patir, Himadri, Sarada, S.K.S, Singh, Saumya, Mathew, Titto, Singh, Bhagwat, Bansal, Anju
Format: Article
Language:English
Subjects:
adverse effects
Altitude
Altitude Sickness - prevention & control
animal models
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antioxidants - pharmacology
Antioxidants - therapeutic use
Atmospheric Pressure
Blood-Brain Barrier - drug effects
brain
Brain - drug effects
Brain - metabolism
Brain - pathology
Brain Edema - blood
Brain Edema - etiology
Brain Edema - prevention & control
Chemoprevention
dexamethasone
Dexamethasone - pharmacology
Dexamethasone - therapeutic use
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
edema
encephalitis
Gene Expression Regulation
Hematological changes
High altitude cerebral edema
histopathology
hypoxia
Hypoxia - blood
Hypoxia - complications
Hypoxia - drug therapy
Inflammation
Lipid Peroxidation - drug effects
Male
Mountaineering
NF-kappa B - metabolism
NFκB
normoxia
Oxidative stress
Oxidative Stress - drug effects
Protein Binding
quercetin
Quercetin - pharmacology
Quercetin - therapeutic use
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species - metabolism
therapeutics
water content
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Summary:The present study was undertaken to elucidate the intervention of quercetin against high altitude cerebral edema (HACE) using male Sprague Dawley rats as an animal model. This study was also programmed to compare and correlate the effect of both quercetin (flavonoid) and dexamethasone (steroid) against HACE. Six groups of animals were designed for this experiment, (I) normoxia, (II) hypoxia (25,000ft, 24h), (III) normoxia+quercetin (50mg/kg body wt), (IV) normoxia+dexamethasone (4mg/kg body wt), (V) hypoxia+quercetin (50mg/kg body wt), (VI) hypoxia+dexamethasone (4mg/kg body wt). Quercetin at 50mg/kg body wt, orally 1h prior to hypoxia exposure, was considered as the optimum dose, due to a significant reduction in the level of brain water content and cerebral transvascular leakage (P
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2012.06.010