The relationship of the BRAF(V600E) mutation and the established prognostic factors in papillary thyroid carcinomas

It has been shown that BRAF(V600E) mutation in papillary thyroid carcinomas (PTC) is associated both with pathogenesis and poor prognosis. In this study, we aimed to investigate the relationship of the BRAF(V600E) mutation and the established prognostic factors in a cohort of Turkish patients with P...

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Bibliographic Details
Published in:Endocrine pathology 2012-09, Vol.23 (3), p.135-140
Main Authors: Kurt, Bülent, Yalçın, Serap, Alagöz, Engin, Karslıoğlu, Yıldırım, Yigit, Nuri, Günal, Armağan, Deveci, M Salih
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Carcinoma - genetics
Carcinoma - pathology
Carcinoma, Papillary
DNA, Neoplasm - analysis
Female
Humans
Lymphatic Metastasis - genetics
Male
Middle Aged
Mutation
Neoplasm Staging
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Prognosis
Proto-Oncogene Proteins B-raf - genetics
Retrospective Studies
Thyroid Cancer, Papillary
Thyroid Neoplasms - genetics
Thyroid Neoplasms - pathology
Turkey
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Summary:It has been shown that BRAF(V600E) mutation in papillary thyroid carcinomas (PTC) is associated both with pathogenesis and poor prognosis. In this study, we aimed to investigate the relationship of the BRAF(V600E) mutation and the established prognostic factors in a cohort of Turkish patients with PTC. Forty-six cases of papillary thyroid carcinoma have been evaluated for the presence of BRAF(V600E) mutation. BRAF(V600E) has been examined by restriction fragment length polymorphism. BRAF(V600E) mutation status has been compared with well-known histopathological and clinical prognostic parameters such as invasion of thyroid capsule, extrathyroidal extension, and the presence of lymph node and/or distant metastasis. We have found that BRAF(V600E) mutation was present in the majority of our cases (40/46). Considering the stage of the disease, five of the negative cases were in stage 1 while the remaining one was in stage 2. Only one BRAF(V600E) negative case has shown extrathyroidal extension and lymph node metastasis. All four patients with distant metastasis had BRAF(V600E) mutation. Statistical analyses revealed that there are no significant relationship between the BRAF(V600E) mutation and the established prognostic factors. We found a relatively higher BRAF(V600E) mutation rate in classical type PTC than in other similar studies. We think that the limited number of our cases may either weaken or mask some potentially important relationship between BRAF(V600E) mutation and the established prognostic factors.
ISSN:1559-0097
DOI:10.1007/s12022-012-9218-7