L-index as a novel index to evaluate both the intensity and duration of lymphopenia after allogeneic hematopoietic stem cell transplantation

We retrospectively investigated L‐index, which evaluates both the intensity and duration of lymphopenia after allogeneic hematopoietic stem cell transplantation (HSCT) (n = 50). L‐index was defined as the area over the lymphocyte curve during lymphopenia (absolute lymphocyte count  3 cells/2 slides...

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Bibliographic Details
Published in:Transplant infectious disease 2012-08, Vol.14 (4), p.364-373
Main Authors: Kimura, S.-I., Wada, H., Sakamoto, K., Ashizawa, M., Sato, M., Terasako, K., Nakasone, H., Kikuchi, M., Okuda, S., Kako, S., Yamazaki, R., Oshima, K., Tanaka, Y., Tanihara, A., Nishida, J., Kanda, Y.
Format: Article
Language:English
Subjects:
absolute lymphocyte count
Adolescent
Adult
allogeneic hematopoietic stem cell transplantation
Area Under Curve
Cytomegalovirus - physiology
cytomegalovirus antigenemia
Cytomegalovirus Infections - virology
Female
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
L-index
Lymphocyte Count - standards
lymphopenia
Lymphopenia - diagnosis
Male
Middle Aged
Retrospective Studies
Transplantation Conditioning
Transplantation, Homologous - adverse effects
Virus Activation
Young Adult
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Summary:We retrospectively investigated L‐index, which evaluates both the intensity and duration of lymphopenia after allogeneic hematopoietic stem cell transplantation (HSCT) (n = 50). L‐index was defined as the area over the lymphocyte curve during lymphopenia (absolute lymphocyte count  3 cells/2 slides by C10/11 method in 30 patients (CMV‐AG ≥ 3 group) and was not detected in 20 patients (CMV‐AG 
ISSN:1398-2273
1399-3062
DOI:10.1111/j.1399-3062.2012.00727.x